7SHT

Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant

Summary for 7SHT

• Entry DOI: 10.2210/pdb7sht/pdb
• EMDB information: 25136
• Descriptor: High affinity immunoglobulin epsilon receptor subunit alpha, Immunoglobulin heavy constant epsilon, clone_7 Variable fragment heavy chain, ... (8 entities in total)
• Functional Keywords: ige, allergy, xolair, omalizumab, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 153771.69

Authors

Pennington, L.F.,Jardetzky, T.S. (deposition date: 2021-10-11, release date: 2021-12-15)

• Primary citation: Pennington, L.F.,Gasser, P.,Kleinboelting, S.,Zhang, C.,Skiniotis, G.,Eggel, A.,Jardetzky, T.S.; Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.; Nat Commun, 12:7069-7069, 2021; PubMed: 34862384; DOI: 10.1038/s41467-021-27397-z

Experimental method

ELECTRON MICROSCOPY (7.29 Å)