7SHT
Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | High affinity immunoglobulin epsilon receptor subunit alpha | polymer | 197 | 22541.8 | 1 | UniProt (P12319) Pfam (PF13927) Pfam (PF13895) In PDB | Homo sapiens (Human) | Fc-epsilon RI-alpha,FcERI,IgE Fc receptor subunit alpha |
2 | B, D | Immunoglobulin heavy constant epsilon | polymer | 322 | 35773.2 | 2 | UniProt (P01854) Pfam (PF07654) In PDB | Homo sapiens (Human) | Ig epsilon chain C region,Ig epsilon chain C region ND |
3 | H, J | clone_7 Variable fragment heavy chain | polymer | 123 | 13451.8 | 2 | Homo sapiens | ||
4 | K, L | clone_7 Variable fragment light chain | polymer | 134 | 14641.9 | 2 | Homo sapiens | ||
5 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
6 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
7 | F, G | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G21381MC) | |||
8 | A, H, J | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: 5 - 172 (UniProt: P12319)
B, D: 228 - 547 (UniProt: P01854)
PDB | External Database | Details |
---|---|---|
Ala -24 | - | expression tag |
Pro -23 | - | expression tag |
Met -22 | - | expression tag |
Ala -21 | - | expression tag |
Glu -20 | - | expression tag |
Gly -19 | - | expression tag |
Gly -18 | - | expression tag |
Gly -17 | - | expression tag |
Gln -16 | - | expression tag |
Asn -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
Gly -6 | - | expression tag |
Gly -5 | - | expression tag |
Glu -4 | - | expression tag |
Asn -3 | - | expression tag |
Leu -2 | - | expression tag |
Tyr -1 | - | expression tag |
Phe 0 | - | expression tag |
Gln 1 | - | expression tag |
Gly 2 | - | expression tag |
Gly 3 | - | expression tag |
Ser 4 | - | expression tag |
Cys 156 | Trp 181 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 226 | - | expression tag |
Ser 227 | - | expression tag |
Cys 335 | Gly 216 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 150275.5 | |
Branched | Number of molecules | 4 |
Total formula weight | 2832.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 153771.7 |