4JYW
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![BU of 4jyw by Molmil](/molmil-images/mine/4jyw) | X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Barinka, C. | 登録日 | 2013-04-01 | 公開日 | 2014-04-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer To be Published
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4JZ0
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4LQG
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1LU0
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![BU of 1lu0 by Molmil](/molmil-images/mine/1lu0) | Atomic Resolution Structure of Squash Trypsin Inhibitor: Unexpected Metal Coordination | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, GLYCEROL, SULFATE ION, ... | 著者 | Thaimattam, R, Tykarska, E, Bierzynski, A, Sheldrick, G.M, Jaskolski, M. | 登録日 | 2002-05-21 | 公開日 | 2002-08-28 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Atomic resolution structure of squash trypsin inhibitor: unexpected metal coordination. Acta Crystallogr.,Sect.D, 58, 2002
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5OOI
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![BU of 5ooi by Molmil](/molmil-images/mine/5ooi) | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P | 分子名称: | 1,2-ETHANEDIOL, 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, ACETATE ION, ... | 著者 | Hochscherf, J, Lindenblatt, D, Witulski, B, Birus, R, Aichele, D, Marminon, C, Bouaziz, Z, Le Borgne, M, Jose, J, Niefind, K. | 登録日 | 2017-08-07 | 公開日 | 2017-12-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '. Pharmaceuticals (Basel), 10, 2017
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4LKA
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![BU of 4lka by Molmil](/molmil-images/mine/4lka) | Crystal Structure of MOZ double PHD finger histone H3K9ac complex | 分子名称: | Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION | 著者 | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | 登録日 | 2013-07-07 | 公開日 | 2013-10-16 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
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4LLB
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![BU of 4llb by Molmil](/molmil-images/mine/4llb) | Crystal Structure of MOZ double PHD finger histone H3K14ac complex | 分子名称: | Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION | 著者 | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | 登録日 | 2013-07-09 | 公開日 | 2013-10-16 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
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6SEC
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![BU of 6sec by Molmil](/molmil-images/mine/6sec) | Cold-adapted beta-D-galactosidase from Arthrobacter sp. 32cBon complex with ONPG | 分子名称: | 2-nitrophenyl beta-D-galactopyranoside, ACETATE ION, Beta-galactosidase, ... | 著者 | Rutkiewicz, M, Bujacz, A, Bujacz, G. | 登録日 | 2019-07-29 | 公開日 | 2019-09-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.768 Å) | 主引用文献 | Active Site Architecture and Reaction Mechanism Determination of Cold Adapted beta-d-galactosidase fromArthrobactersp. 32cB. Int J Mol Sci, 20, 2019
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4LK9
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![BU of 4lk9 by Molmil](/molmil-images/mine/4lk9) | Crystal Structure of MOZ double PHD finger histone H3 tail complex | 分子名称: | Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION | 著者 | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | 登録日 | 2013-07-07 | 公開日 | 2013-10-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
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4L9P
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![BU of 4l9p by Molmil](/molmil-images/mine/4l9p) | Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, CaaX farnesyltransferase alpha subunit Ram2, ... | 著者 | Mabanglo, M.F, Hast, M.A, Beese, L.S. | 登録日 | 2013-06-18 | 公開日 | 2014-01-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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4LNG
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![BU of 4lng by Molmil](/molmil-images/mine/4lng) | Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib | 分子名称: | 1,2-ETHANEDIOL, 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, CaaX farnesyltransferase alpha subunit Ram2, ... | 著者 | Mabanglo, M.F, Hast, M.A, Beese, L.S. | 登録日 | 2013-07-11 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | 主引用文献 | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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4LNB
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![BU of 4lnb by Molmil](/molmil-images/mine/4lnb) | Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5 | 分子名称: | 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ... | 著者 | Mabanglo, M.F, Hast, M.A, Beese, L.S. | 登録日 | 2013-07-11 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | 主引用文献 | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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4MBG
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![BU of 4mbg by Molmil](/molmil-images/mine/4mbg) | Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate | 分子名称: | 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ... | 著者 | Mabanglo, M.F, Hast, M.A, Beese, L.S. | 登録日 | 2013-08-19 | 公開日 | 2014-01-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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3HVD
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![BU of 3hvd by Molmil](/molmil-images/mine/3hvd) | The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes | 分子名称: | CALCIUM ION, Protective antigen | 著者 | Kintzer, A.F, Dong, K.C, Berger, J.M, Krantz, B.A. | 登録日 | 2009-06-15 | 公開日 | 2009-08-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.209 Å) | 主引用文献 | The protective antigen component of anthrax toxin forms functional octameric complexes. J.Mol.Biol., 392, 2009
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7T0D
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![BU of 7t0d by Molmil](/molmil-images/mine/7t0d) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-propyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.906 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0C
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![BU of 7t0c by Molmil](/molmil-images/mine/7t0c) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0E
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![BU of 7t0e by Molmil](/molmil-images/mine/7t0e) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2b | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-(3-chlorophenyl)piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.223 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0B
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![BU of 7t0b by Molmil](/molmil-images/mine/7t0b) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2g | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-fluorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.026 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0A
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![BU of 7t0a by Molmil](/molmil-images/mine/7t0a) | Cryptococcus neoformans protein farnesyltransferase co-crystallized with FPP and inhibitor 2f | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T09
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![BU of 7t09 by Molmil](/molmil-images/mine/7t09) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2d | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}benzonitrile, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.984 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T08
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![BU of 7t08 by Molmil](/molmil-images/mine/7t08) | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}-2-fluorobenzonitrile, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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1QNU
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![BU of 1qnu by Molmil](/molmil-images/mine/1qnu) | Shiga-Like Toxin I B Subunit Complexed with the Bridged-Starfish Inhibitor | 分子名称: | ETHYL-CARBAMIC ACID METHYL ESTER, METHYL-CARBAMIC ACID ETHYL ESTER, Shiga toxin 1 variant B subunit, ... | 著者 | Pannu, N.S, Hayakawa, K, Read, R.J. | 登録日 | 1999-10-21 | 公開日 | 2000-04-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands. Nature, 403, 2000
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4LJN
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![BU of 4ljn by Molmil](/molmil-images/mine/4ljn) | Crystal Structure of MOZ double PHD finger | 分子名称: | Histone acetyltransferase KAT6A, ZINC ION | 著者 | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | 登録日 | 2013-07-05 | 公開日 | 2013-10-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
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2XZE
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2GD5
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![BU of 2gd5 by Molmil](/molmil-images/mine/2gd5) | Structural basis for budding by the ESCRTIII factor CHMP3 | 分子名称: | Charged multivesicular body protein 3 | 著者 | Muziol, T.M, Pineda-Molina, E, Ravelli, R.B, Zamborlini, A, Usami, Y, Gottlinger, H, Weissenhorn, W. | 登録日 | 2006-03-15 | 公開日 | 2006-06-13 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis for Budding by the ESCRT-III Factor CHMP3. Dev.Cell, 10, 2006
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