4LQG
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor CTT1056
Summary for 4LQG
Entry DOI | 10.2210/pdb4lqg/pdb |
Related PRD ID | PRD_001140 |
Descriptor | Glutamate carboxypeptidase 2, N-(4-fluorobenzoyl)-L-gamma-glutamyl-5-{[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]oxy}-L-norvaline, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | peptidase, hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 84164.10 |
Authors | Barinka, C.,Skultetyova, L. (deposition date: 2013-07-18, release date: 2014-12-31, Last modification date: 2020-07-29) |
Primary citation | Dannoon, S.,Ganguly, T.,Cahaya, H.,Geruntho, J.J.,Galliher, M.S.,Beyer, S.K.,Choy, C.J.,Hopkins, M.R.,Regan, M.,Blecha, J.E.,Skultetyova, L.,Drake, C.R.,Jivan, S.,Barinka, C.,Jones, E.F.,Berkman, C.E.,VanBrocklin, H.F. Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer. J.Med.Chem., 59:5684-5694, 2016 Cited by PubMed: 27228467DOI: 10.1021/acs.jmedchem.5b01850 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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