7N28
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3LBL
| Structure of human MDM2 protein in complex with Mi-63-analog | 分子名称: | (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2 | 著者 | Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. | 登録日 | 2010-01-08 | 公開日 | 2010-03-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
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3LBK
| Structure of human MDM2 protein in complex with a small molecule inhibitor | 分子名称: | 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. | 登録日 | 2010-01-08 | 公開日 | 2010-03-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
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3LBJ
| Structure of human MDMX protein in complex with a small molecule inhibitor | 分子名称: | N-[(3S)-1-({6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indol-2-yl}carbonyl)pyrrolidin-3-yl]-N,N',N'-trimethylpropane-1,3-diamine, Protein Mdm4, SULFATE ION | 著者 | Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. | 登録日 | 2010-01-08 | 公開日 | 2010-03-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
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4DBF
| Crystal structures of Cg1458 | 分子名称: | 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE, MAGNESIUM ION | 著者 | Ran, T.T, Xu, D.Q, Wang, W.W, Gao, Y.Y, Wang, M.T. | 登録日 | 2012-01-15 | 公開日 | 2012-11-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for FAH family. Biochem.J., 449, 2013
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4DBH
| Crystal structure of Cg1458 with inhibitor | 分子名称: | 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE, MAGNESIUM ION, OXALATE ION | 著者 | Ran, T.T, Wang, W.W, Xu, D.Q, Gao, Y.Y. | 登録日 | 2012-01-15 | 公開日 | 2012-11-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for FAH family. Biochem.J., 449, 2013
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5WI9
| Crystal structure of KL with an agonist Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 39F7 Fab heavy chain, ... | 著者 | Johnstone, S, Min, X, Wang, Z. | 登録日 | 2017-07-18 | 公開日 | 2018-07-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Agonistic beta-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions. J. Biol. Chem., 293, 2018
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5BNQ
| Crystal structure of hRANKL-mRANK complex | 分子名称: | CHLORIDE ION, PHOSPHATE ION, SODIUM ION, ... | 著者 | Ren, J. | 登録日 | 2015-05-26 | 公開日 | 2015-10-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis. Sci Rep, 5, 2015
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4FFW
| Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin | 分子名称: | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, Dipeptidyl peptidase 4, Fab heavy chain, ... | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | 登録日 | 2012-06-01 | 公開日 | 2012-12-12 | 最終更新日 | 2021-05-19 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition To be published
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4FFV
| Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab | 分子名称: | 11A19 Fab heavy chain, 11A19 Fab light chain, Dipeptidyl peptidase 4 | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | 登録日 | 2012-06-01 | 公開日 | 2012-12-12 | 最終更新日 | 2021-05-19 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition To be published
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4H4C
| IspH in complex with (E)-4-fluoro-3-methylbut-2-enyl diphosphate | 分子名称: | (2E)-4-fluoro-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER | 著者 | Span, I, Eisenreich, W, Jauch, J, Bacher, A, Groll, M. | 登録日 | 2012-09-17 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe(4) S(4) ] Protein IspH. Angew.Chem.Int.Ed.Engl., 52, 2013
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5CFF
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7YMI
| PSII-Pcb Dimer of Acaryochloris Marina | 分子名称: | (1R,2S)-4-{(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl}-2,5,5-trimethylcyclohex-3-en-1-ol, (6'R,11cis,11'cis,13cis,15cis)-4',5'-didehydro-5',6'-dihydro-beta,beta-carotene, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | 著者 | Shen, L.L, Gao, Y.Z, Wang, W.D, Zhang, X, Shen, J.R, Wang, P.Y, Han, G.Y. | 登録日 | 2022-07-28 | 公開日 | 2023-08-16 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of a unique PSII-Pcb tetrameric megacomplex in a chlorophyll d -containing cyanobacterium. Sci Adv, 10, 2024
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7YMM
| PSII-Pcb Tetramer of Acaryochloris Marina | 分子名称: | (1R,2S)-4-{(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl}-2,5,5-trimethylcyclohex-3-en-1-ol, (6'R,11cis,11'cis,13cis,15cis)-4',5'-didehydro-5',6'-dihydro-beta,beta-carotene, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | 著者 | Shen, L.L, Gao, Y.Z, Wang, W.D, Zhang, X, Shen, J.R, Wang, P.Y, Han, G.Y. | 登録日 | 2022-07-28 | 公開日 | 2023-08-16 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of a unique PSII-Pcb tetrameric megacomplex in a chlorophyll d -containing cyanobacterium. Sci Adv, 10, 2024
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2RI5
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2RHU
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2RI7
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2RHX
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2RI3
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8D9N
| CryoEM structures of bAE1 captured in multiple states. | 分子名称: | Anion exchange protein | 著者 | Zhekova, H.R, Wang, W.G, Jiang, J.S, Tsirulnikov, K, Muhammad-Khan, G.H, Azimov, R, Abuladze, N, Kao, L, Newman, D, Noskov, S.Y, Tieleman, P, Zhou, Z.H, Pushkin, A, Kurtz, I. | 登録日 | 2022-06-10 | 公開日 | 2023-01-25 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations. Commun Biol, 5, 2022
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2RHZ
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5YU9
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8E34
| CryoEM structures of bAE1 captured in multiple states | 分子名称: | Anion exchange protein | 著者 | Zhekova, H.R, Wang, W.G, Jiang, J.S, Tsirulnikov, K, Muhammad-Khan, G.H, Azimov, R, Abuladze, N, Kao, L, Newman, D, Noskov, S.Y, Tieleman, P, Zhou, Z.H, Pushkin, A, Kurtz, I. | 登録日 | 2022-08-16 | 公開日 | 2023-01-25 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations. Commun Biol, 5, 2022
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2RI2
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2RHI
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