8FYD
| Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | 分子名称: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
|
|
8FYA
| Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
|
|
8FYB
| Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | 分子名称: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
|
|
8FYC
| Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | 分子名称: | Cas1, Cas2-DEDDh, DEDDh, ... | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
|
|
8FY9
| Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER) | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | 登録日 | 2023-01-25 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
|
|
7REC
| Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC | 分子名称: | 5-hydroxydiclofenac, Calcium/calmodulin-dependent protein kinase type II subunit alpha, SODIUM ION | 著者 | McSpadden, E.D, Chi, C.C, Gee, C.L, Kuriyan, J. | 登録日 | 2021-07-12 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
6RJK
| Structure of virulence factor SghA from Agrobacterium tumefaciens | 分子名称: | Beta-glucosidase | 著者 | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | 登録日 | 2019-04-27 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.922 Å) | 主引用文献 | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6RK2
| Complex structure of virulence factor SghA mutant with its substrate SAG | 分子名称: | 2-(alpha-L-altropyranosyloxy)benzoic acid, Beta-glucosidase | 著者 | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | 登録日 | 2019-04-30 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6RJM
| Complex structure of virulence factor SghA and its hydrolysis product glucose | 分子名称: | Beta-glucosidase, alpha-D-glucopyranose | 著者 | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | 登録日 | 2019-04-27 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.112 Å) | 主引用文献 | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6IS2
| |
6RJO
| Complex structure of virulence factor SghA with its substrate analog salicin | 分子名称: | 2-(hydroxymethyl)phenyl beta-D-glucopyranoside, Beta-glucosidase | 著者 | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | 登録日 | 2019-04-28 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.804 Å) | 主引用文献 | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6IS3
| |
4ISH
| Structure of FACTOR VIIA in complex with the inhibitor BMS-593214 also known as 2'-[(6R,6AR,11BR)-2-CARBAMIMIDOYL-6,6A,7,11B-TETRAHYDRO-5H-INDENO[2,1-C]QUINOLIN-6-YL]-5'-HYDROXY-4'-METHOXYBIPHENYL-4-CARBOXYLIC ACID | 分子名称: | 2'-[(6R,6aR,11bR)-2-carbamimidoyl-6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolin-6-yl]-5'-hydroxy-4'-methoxybiphenyl-4-carboxylic acid, CALCIUM ION, Factor VII heavy chain, ... | 著者 | Wei, A. | 登録日 | 2013-01-16 | 公開日 | 2013-03-20 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor. Bioorg.Med.Chem.Lett., 23, 2013
|
|
8GOU
| Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH003 Fab heavy chain, ... | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-25 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
|
|
8GPY
| Crystal structure of Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv | 分子名称: | Spike protein S1, scFv | 著者 | Gao, Y.X, Song, Z.D, Wang, W.M, Guo, Y. | 登録日 | 2022-08-27 | 公開日 | 2023-06-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
|
|
7VHR
| Apostichopus japonicus ferritin | 分子名称: | Ferritin, MAGNESIUM ION | 著者 | Wu, Y, Su, X.R, Ming, T.H. | 登録日 | 2021-09-22 | 公開日 | 2022-03-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.756 Å) | 主引用文献 | Crystallographic characterization of a marine invertebrate ferritin from the sea cucumber Apostichopus japonicus. Febs Open Bio, 12, 2022
|
|
7VOA
| |
7V4X
| |
7V6V
| |
7V50
| |
7V51
| BVMO_negative mutant D432V | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Putative flavin-binding monooxygenase | 著者 | Wu, Y, Yu, H.-L. | 登録日 | 2021-08-16 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Precise regulation of the substrate selectivity of Baeyer-Villiger monooxygenase to minimize overoxidation of prazole sulfoxides. CHINESE J CATAL, 51, 2023
|
|
4JVE
| Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid | 分子名称: | (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid, E3 ubiquitin-protein ligase Mdm2 | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | 登録日 | 2013-03-25 | 公開日 | 2013-05-01 | 最終更新日 | 2013-06-05 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
|
|
4JV9
| Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one | 分子名称: | (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | 登録日 | 2013-03-25 | 公開日 | 2013-05-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
|
|
6OV1
| Structure of Staphylococcus aureus RNase P protein mutant with defective mRNA degradation activity | 分子名称: | Ribonuclease P protein component | 著者 | Ha, L, Colquhoun, J, Noinaj, N, Das, C, Dunman, P, Flaherty, D.P. | 登録日 | 2019-05-06 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Genetic and biochemical characterization of Staphylococcus aureus RnpA To Be Published
|
|
4JV7
| Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one | 分子名称: | (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | 登録日 | 2013-03-25 | 公開日 | 2013-05-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56, 2013
|
|