3Q96
 
 | | B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor | | 分子名称: | (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide, Serine/threonine-protein kinase B-raf | | 著者 | Sintchak, M.D, Aertgeerts, K, Yano, J. | | 登録日 | 2011-01-07 | | 公開日 | 2011-03-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors.
J.Med.Chem., 54, 2011
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8HWT
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8HWS
 | | The complex structure of Omicron BA.4 RBD with BD604, S309, and S304 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD-604 Fab Heavy chain, BD-604 Fab Light chain, ... | | 著者 | He, Q.W, Xu, Z.P, Xie, Y.F. | | 登録日 | 2023-01-02 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | | 主引用文献 | An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB.
Cell Rep Med, 4, 2023
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8FYA
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYB
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYC
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DEDDh, ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FY9
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER) | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYD
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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6E6Z
 | | Structure of Wild Type Human Transthyretin in Complex with Tafamidis | | 分子名称: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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6E77
 | | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Tafamidis | | 分子名称: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | | 著者 | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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6E70
 | | Structure of Wild Type Human Transthyretin in Complex with Diflunisal | | 分子名称: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, CALCIUM ION, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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6E76
 | | Structure of Human Transthyretin Asp38Ala/Thr119Met Mutant | | 分子名称: | ACETATE ION, GLYCEROL, SULFATE ION, ... | | 著者 | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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6OV1
 | | Structure of Staphylococcus aureus RNase P protein mutant with defective mRNA degradation activity | | 分子名称: | Ribonuclease P protein component | | 著者 | Ha, L, Colquhoun, J, Noinaj, N, Das, C, Dunman, P, Flaherty, D.P. | | 登録日 | 2019-05-06 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Genetic and biochemical characterization of Staphylococcus aureus RnpA
To Be Published
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6E72
 | | Structure of Human Transthyretin Val30Met Mutant in Complex with Tafamidis | | 分子名称: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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6E71
 | | Structure of Human Transthyretin Val30Met/Thr119Met Mutant | | 分子名称: | DI(HYDROXYETHYL)ETHER, Transthyretin | | 著者 | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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6E78
 | | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Diflunisal | | 分子名称: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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5X5M
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8JVA
 | | Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N235 and S2L20 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 heavy chain, S2L20 light chain, ... | | 著者 | Liu, B, Liu, H.H, Han, P, Qi, J.X. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | | 主引用文献 | Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain.
Signal Transduct Target Ther, 9, 2024
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4JV9
 | | Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one | | 分子名称: | (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | | 登録日 | 2013-03-25 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
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8HEF
 | | The Crystal structure of deuterated S-217622 (Ensitrelvir) bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 | | 分子名称: | 3C-like proteinase, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, GLYCEROL | | 著者 | Yan, M, Zhang, H. | | 登録日 | 2022-11-08 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2.
Antiviral Res., 213, 2023
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4JV7
 | | Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one | | 分子名称: | (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | | 登録日 | 2013-03-25 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
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4JVR
 | | Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide | | 分子名称: | (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2 | | 著者 | Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C. | | 登録日 | 2013-03-26 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
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8HIV
 | | The structure of apo-SoBcmB with Fe(II) and AKG | | 分子名称: | 2-OXOGLUTARIC ACID, FE (II) ION, Fe/2OG dependent dioxygenase | | 著者 | Wu, L, Zhou, J.H. | | 登録日 | 2022-11-22 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.2000308 Å) | | 主引用文献 | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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6E75
 | | Structure of Human Transthyretin Asp38Ala Mutant | | 分子名称: | ACETATE ION, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
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7DL0
 | | The mutant E310G/A314Y of 3,5-DAHDHcca complex with NADPH | | 分子名称: | 1,2-ETHANEDIOL, 3,5-diaminohexanoate dehydrogenase, CHLORIDE ION, ... | | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | | 登録日 | 2020-11-25 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.
Angew.Chem.Int.Ed.Engl., 60, 2021
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