8BAQ
 
 | | E. coli C7 DarT1 in complex with NAD+ | | 分子名称: | 1,2-ETHANEDIOL, DarT ssDNA thymidine ADP-ribosyltransferase family protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Schuller, M, Ariza, A. | | 登録日 | 2022-10-11 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular basis for the reversible ADP-ribosylation of guanosine bases.
Mol.Cell, 83, 2023
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6O3I
 | | Crystal Structure of Human IDO1 bound to navoximod (NLG-919) | | 分子名称: | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, trans-4-{(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl}cyclohexan-1-ol | | 著者 | Harris, S.F, Oh, A. | | 登録日 | 2019-02-26 | | 公開日 | 2019-07-17 | | 最終更新日 | 2019-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.
J.Med.Chem., 62, 2019
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8BAU
 | | Phytophthora nicotianae var. parasitica NADAR in complex with ADP-ribose | | 分子名称: | 1,2-ETHANEDIOL, NADAR domain-containing protein, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | 著者 | Schuller, M, Ariza, A. | | 登録日 | 2022-10-11 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Molecular basis for the reversible ADP-ribosylation of guanosine bases.
Mol.Cell, 83, 2023
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3I2C
 | | Crystal structure of anti-IL-23 antibody CNTO4088 | | 分子名称: | CNTO4088 HEAVY CHAIN, CNTO4088 LIGHT CHAIN, GLYCEROL | | 著者 | Teplyakov, A, Obmolova, G, Gilliland, G.L. | | 登録日 | 2009-06-29 | | 公開日 | 2009-07-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.
Acta Crystallogr.,Sect.F, 66, 2010
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5DK0
 | | Fc Heterodimer Design 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A | | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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5E27
 | | The structure of Resuscitation Promoting Factor B from M. tuberculosis reveals unexpected ubiquitin-like domains | | 分子名称: | Resuscitation-promoting factor RpfB | | 著者 | Ruggiero, A, Squeglia, F, Romano, M, Vitagliano, L, De Simone, A, Berisio, R. | | 登録日 | 2015-09-30 | | 公開日 | 2015-11-18 | | 最終更新日 | 2015-12-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains.
Biochim.Biophys.Acta, 1860, 2015
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5DS0
 | | Crystal structure of TET aminopeptidase from marine sediment archaeon Thaumarchaeota archaeon SCGC AB-539-E09 | | 分子名称: | COBALT (II) ION, GLYCEROL, Peptidase M42 | | 著者 | Michalska, K, Chhor, G, Mootz, J, Endres, M, Jedrzejczak, R, Babnigg, G, Steen, A, Lloyd, K, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2015-09-16 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of TET aminopeptidase from marine sediment archaeon Thaumarchaeota archaeon SCGC AB-539-E09
To Be Published
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5ZAU
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5DJX
 | | Fc Heterodimer Design 2.9 L368M/K370E + E357A/S364G | | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | | 登録日 | 2015-09-02 | | 公開日 | 2016-03-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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1HIZ
 | | Xylanase T6 (Xt6) from Bacillus Stearothermophilus | | 分子名称: | ENDO-1,4-BETA-XYLANASE, SULFATE ION, alpha-D-galactopyranose, ... | | 著者 | Sainz, G, Tepplitsky, A, Stojanoff, V, Thompson, A, Shoham, Y, Shoham, G. | | 登録日 | 2001-01-05 | | 公開日 | 2002-01-04 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure Determination of the Extracellular Xylanase from Geobacillus Stearothermophilus by Selenomethionyl MAD Phasing
Acta Crystallogr.,Sect.D, 60, 2004
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4JW2
 | | Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep) | | 分子名称: | 1,2-ETHANEDIOL, A3 artificial protein, bA3-2: binder of A3 protein | | 著者 | Guellouz, A, Valerio-Lepiniec, M, Urvoas, A, Chevrel, A, Graille, M, Fourati-Kammoun, Z, Desmadril, M, van Tilbeurgh, H, Minard, P. | | 登録日 | 2013-03-27 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep).
Plos One, 8, 2013
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5DN9
 | | Crystal structure of Candida boidinii formate dehydrogenase complexed with NAD+ and azide | | 分子名称: | AZIDE ION, CHLORIDE ION, FDH, ... | | 著者 | Guo, Q, Gakhar, L, Wichersham, K, Francis, K, Vardi-Kilshtain, A, Major, D.T, Cheatum, C.M, Kohen, A. | | 登録日 | 2015-09-09 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.
Biochemistry, 55, 2016
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6Z2C
 | | Engineered lipocalin C3A5 in complex with a transition state analog | | 分子名称: | 1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione, Neutrophil gelatinase-associated lipocalin | | 著者 | Skerra, A, Eichinger, A. | | 登録日 | 2020-05-15 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of an engineered lipocalin that catalyzes a Diels-Alder reaction
To be published
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6NZL
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6Z2T
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5DPO
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5DVK
 | | Fc Design 7.7 B chain homodimer T366V/K409I | | 分子名称: | Ig gamma-1 chain C region | | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | | 登録日 | 2015-09-21 | | 公開日 | 2016-03-30 | | 最終更新日 | 2016-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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6Z6Z
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6YWW
 | | MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion | | 分子名称: | DNA (5'-D(*AP*TP*AP*TP*AP*AP*TP*TP*GP*TP*GP*TP*GP*TP*GP*TP*GP*CP*AP*G)-3'), DNA/RNA (5'-D(*TP*CP*TP*GP*CP*AP*CP*A)-R(P*(5HC))-D(P*AP*CP*AP*CP*AP*AP*TP*TP*AP*TP*A)-3'), Truncated methyl CpG binding protein 2 transcript 1 | | 著者 | Ibrahim, A, Papin, C, Mohideen-Abdul, K, Gras, S.L, Stoll, I, Bronner, C, Dimitrov, S, Klaholz, B.P, Hamiche, A. | | 登録日 | 2020-04-30 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | | 主引用文献 | MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion.
Science, 372, 2021
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5DYF
 | | The crystal structure of Aminopeptidase N in complex with N-benzyl-1,2-diaminoethylphosphonic acid | | 分子名称: | Aminopeptidase N, GLYCEROL, IMIDAZOLE, ... | | 著者 | Nocek, B, Joachimiak, A, Vassiliou, S, Berlicki, L, Mucha, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2015-09-24 | | 公開日 | 2015-11-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.854 Å) | | 主引用文献 | The crystal structure of Aminopeptidase N in complex with N-benzyl-1,2-diaminoethylphosphonic acid
To Be Published
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6QZH
 | | Structure of the human CC Chemokine Receptor 7 in complex with the intracellular allosteric antagonist Cmp2105 and the insertion protein Sialidase NanA | | 分子名称: | 3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide, C-C chemokine receptor type 7,Sialidase A,C-C chemokine receptor type 7, D(-)-TARTARIC ACID, ... | | 著者 | Jaeger, K, Bruenle, S, Weinert, T, Guba, W, Muehle, J, Miyazaki, T, Weber, M, Furrer, A, Haenggi, N, Tetaz, T, Huang, C.Y, Mattle, D, Vonach, J.M, Gast, A, Kuglstatter, A, Rudolph, M.G, Nogly, P, Benz, J, Dawson, R.J.P, Standfuss, J. | | 登録日 | 2019-03-11 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.
Cell, 178, 2019
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8B7P
 | | Crystal structure of an AA9 LPMO from Aspergillus nidulans, AnLPMOC | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Endo-beta-1,4-glucanase D | | 著者 | Males, A, Rafael Fanchini Terrasan, C, Davies, G.J, Walton, P.H. | | 登録日 | 2022-09-30 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Characterisation of lytic polysaccharide monooxygenases from Aspergillus nidulans
To Be Published
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8F11
 | | T4 lysozyme with a 2,6-diazaadamantane nitroxide (DZD) spin label | | 分子名称: | 1-[(1r,3r,5r,7r)-6-hydroxy-2,6-diazatricyclo[3.3.1.1~3,7~]decan-2-yl]ethan-1-one, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | | 著者 | Wilson, M.A, Madzelan, P, Rajca, A, Stein, R, Yang, Z. | | 登録日 | 2022-11-04 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | Cucurbit[7]uril Enhances Distance Measurements of Spin-Labeled Proteins.
J.Am.Chem.Soc., 145, 2023
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6ZGO
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5HOD
 | | Structure of LHX4 transcription factor complexed with DNA | | 分子名称: | DNA (5'-D(P*AP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*GP*TP*AP*AP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*TP*TP*AP*CP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*T)-3'), LIM/homeobox protein Lhx4 | | 著者 | Morgunova, E, Yin, Y, Popov, A, Taipale, J. | | 登録日 | 2016-01-19 | | 公開日 | 2017-02-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.682 Å) | | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
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