6QZH
Structure of the human CC Chemokine Receptor 7 in complex with the intracellular allosteric antagonist Cmp2105 and the insertion protein Sialidase NanA
Summary for 6QZH
Entry DOI | 10.2210/pdb6qzh/pdb |
Descriptor | C-C chemokine receptor type 7,Sialidase A,C-C chemokine receptor type 7, TRIETHYLENE GLYCOL, 3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide, ... (6 entities in total) |
Functional Keywords | gpcr, chemokine receptor, small molecule, allosteric modulator, insertion protein, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 89289.41 |
Authors | Jaeger, K.,Bruenle, S.,Weinert, T.,Guba, W.,Muehle, J.,Miyazaki, T.,Weber, M.,Furrer, A.,Haenggi, N.,Tetaz, T.,Huang, C.Y.,Mattle, D.,Vonach, J.M.,Gast, A.,Kuglstatter, A.,Rudolph, M.G.,Nogly, P.,Benz, J.,Dawson, R.J.P.,Standfuss, J. (deposition date: 2019-03-11, release date: 2019-09-04, Last modification date: 2024-01-24) |
Primary citation | Jaeger, K.,Bruenle, S.,Weinert, T.,Guba, W.,Muehle, J.,Miyazaki, T.,Weber, M.,Furrer, A.,Haenggi, N.,Tetaz, T.,Huang, C.Y.,Mattle, D.,Vonach, J.M.,Gast, A.,Kuglstatter, A.,Rudolph, M.G.,Nogly, P.,Benz, J.,Dawson, R.J.P.,Standfuss, J. Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7. Cell, 178:1222-1230.e10, 2019 Cited by PubMed: 31442409DOI: 10.1016/j.cell.2019.07.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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