6QZH
Structure of the human CC Chemokine Receptor 7 in complex with the intracellular allosteric antagonist Cmp2105 and the insertion protein Sialidase NanA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | C-C chemokine receptor type 7,Sialidase A,C-C chemokine receptor type 7 | polymer | 785 | 88340.5 | 1 | UniProt (P32248) UniProt (P62575) Pfam (PF00001) Pfam (PF02012) UniProt (by SIFTS) (P62576) In PDB | Homo sapiens (Human) | CCR-7,BLR2,CDw197,Epstein-Barr virus-induced G-protein coupled receptor 1,EBV-induced G-protein coupled receptor 1,MIP-3 beta receptor,Neuraminidase A,CCR-7,BLR2,CDw197,Epstein-Barr virus-induced G-protein coupled receptor 1,EBV-induced G-protein coupled receptor 1,MIP-3 beta receptor |
| 2 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 3 | A | 3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide | non-polymer | 475.6 | 1 | Chemie (JLW) | |||
| 4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | A | D(-)-TARTARIC ACID | non-polymer | 150.1 | 2 | Chemie (TAR) | |||
| 6 | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A: 46 - 247 (UniProt: P32248)
A: 1001 - 1470 (UniProt: P62575)
A: 257 - 348 (UniProt: P32248)
| PDB | External Database | Details |
|---|---|---|
| Gly 42 | - | expression tag |
| Pro 43 | - | expression tag |
| Gly 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Trp 145 | Leu 145 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 1016 | Lys 337 | conflict |
| Asp 1191 | Asn 512 | conflict |
| Asp 1278 | Asn 599 | conflict |
| Val 1285 | Ile 606 | conflict |
| Glu 1466 | Asp 787 | conflict |
| Ser 1471 | - | linker |
| Lys 1472 | - | linker |
| Gly 255 | - | linker |
| His 256 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 248 | - | linker |
| Lys 249 | - | linker |
| Leu 250 | - | linker |
| His 251 | - | linker |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Arg 351 | - | expression tag |
| Leu 352 | - | expression tag |
| Glu 353 | - | expression tag |
| Val 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Phe 356 | - | expression tag |
| Gln 357 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 88340.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 948.9 | |
| All* | Total formula weight | 89289.4 |
