5YFP
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![BU of 5yfp by Molmil](/molmil-images/mine/5yfp) | Cryo-EM Structure of the Exocyst Complex | 分子名称: | Exocyst complex component EXO70, Exocyst complex component EXO84, Exocyst complex component SEC10, ... | 著者 | Mei, K, Li, Y, Wang, S, Shao, G, Wang, J, Ding, Y, Luo, G, Yue, P, Liu, J.J, Wang, X, Dong, M.Q, Guo, W, Wang, H.W. | 登録日 | 2017-09-21 | 公開日 | 2018-01-31 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of the exocyst complex Nat. Struct. Mol. Biol., 25, 2018
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4AW2
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![BU of 4aw2 by Molmil](/molmil-images/mine/4aw2) | Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha) | 分子名称: | 1,2-ETHANEDIOL, 5,11-dimethyl-1-oxo-2,6-dihydro-1h-pyrido[4,3-b]carbazol-9-yl benzoate, SERINE/THREONINE-PROTEIN KINASE MRCK ALPHA | 著者 | Elkins, J.M, Muniz, J.R.C, Tan, I, Leung, T, Lafanechere, L, Prudent, R, Abdul Azeez, K, Szklarz, M, Phillips, C, Wang, J, von Delft, F, Bountra, C, Edwards, A, Knapp, S. | 登録日 | 2012-05-30 | 公開日 | 2012-06-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Cdc42 Binding Protein Kinase Alpha (Mrck Alpha) To be Published
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5UZ0
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![BU of 5uz0 by Molmil](/molmil-images/mine/5uz0) | Crystal structure of AICARFT bound to an antifolate | 分子名称: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, MAGNESIUM ION, ... | 著者 | Atwell, S, Wang, Y, Fales, K.R, Clawson, D, Wang, J. | 登録日 | 2017-02-24 | 公開日 | 2018-01-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J. Med. Chem., 60, 2017
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6XBG
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![BU of 6xbg by Molmil](/molmil-images/mine/6xbg) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW246 | 分子名称: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-05 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6YG6
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![BU of 6yg6 by Molmil](/molmil-images/mine/6yg6) | Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor TL10-105 | 分子名称: | 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 7, ~{N}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{S})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | 著者 | Chaikuad, A, Tan, L, Wang, J, Liang, Y, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-03-27 | 公開日 | 2020-08-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chem Biol, 27, 2020
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4BEV
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![BU of 4bev by Molmil](/molmil-images/mine/4bev) | ATPase crystal structure with bound phosphate analogue | 分子名称: | COPPER EFFLUX ATPASE, MAGNESIUM ION, TRIFLUOROMAGNESATE | 著者 | Mattle, D, Drachmann, N.D, Liu, X.Y, Gourdon, P, Pedersen, B.P, Morth, P, Wang, J, Nissen, P. | 登録日 | 2013-03-12 | 公開日 | 2014-04-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.583 Å) | 主引用文献 | ATPase Crystal Structure with Bound Phosphate Analogue To be Published
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6XBI
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![BU of 6xbi by Molmil](/molmil-images/mine/6xbi) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW248 | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-06 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XFN
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![BU of 6xfn by Molmil](/molmil-images/mine/6xfn) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW243 | 分子名称: | 3C-like proteinase, GLYCEROL, UAW243 | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-15 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XBH
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![BU of 6xbh by Molmil](/molmil-images/mine/6xbh) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW247 | 分子名称: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-06 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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5ZCS
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![BU of 5zcs by Molmil](/molmil-images/mine/5zcs) | 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | 分子名称: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | 著者 | Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. | 登録日 | 2018-02-20 | 公開日 | 2018-03-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
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5G2X
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![BU of 5g2x by Molmil](/molmil-images/mine/5g2x) | Structure a of Group II Intron Complexed with its Reverse Transcriptase | 分子名称: | 5'-R(*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*CP)-3', GROUP II INTRON, GROUP II INTRON-ENCODED PROTEIN LTRA | 著者 | Qu, G, Kaushal, P.S, Wang, J, Shigematsu, H, Piazza, C.L, Agrawal, R.K, Belfort, M, Wang, H.W. | 登録日 | 2016-04-16 | 公開日 | 2016-05-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of a Group II Intron in Complex with its Reverse Transcriptase. Nat.Struct.Mol.Biol., 23, 2016
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3ZON
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![BU of 3zon by Molmil](/molmil-images/mine/3zon) | Human TYK2 pseudokinase domain bound to a kinase inhibitor | 分子名称: | 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE, NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 | 著者 | Elkins, J.M, Wang, J, Krojer, T, Savitsky, P, Chalk, R, Daga, N, Salah, E, Berridge, G, Picaud, S, von Delft, F, Bountra, C, Edwards, A, Knapp, S. | 登録日 | 2013-02-22 | 公開日 | 2013-04-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Human Tyk2 Pseudokinase Domain Bound to a Kinase Inhibitor To be Published
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1NMI
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![BU of 1nmi by Molmil](/molmil-images/mine/1nmi) | Solution structure of the imidazole complex of iso-1 cytochrome c | 分子名称: | Cytochrome c, iso-1, HEME C, ... | 著者 | Yao, Y, Tong, Y, Liu, G, Wang, J, Zheng, J, Tang, W. | 登録日 | 2003-01-10 | 公開日 | 2003-02-04 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the imidazole complex of iso-1 cytochrome c To be Published
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4EAG
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![BU of 4eag by Molmil](/molmil-images/mine/4eag) | Co-crystal structure of an chimeric AMPK core with ATP | 分子名称: | 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | 登録日 | 2012-03-22 | 公開日 | 2012-06-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
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4EAL
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![BU of 4eal by Molmil](/molmil-images/mine/4eal) | Co-crystal of AMPK core with ATP soaked with AMP | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | 登録日 | 2012-03-22 | 公開日 | 2012-06-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.506 Å) | 主引用文献 | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
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4B99
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![BU of 4b99 by Molmil](/molmil-images/mine/4b99) | Crystal Structure of MAPK7 (ERK5) with inhibitor | 分子名称: | 11-cyclopentyl-2-[[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl-phenyl]amino]-5-methyl-pyrimido[4,5-b][1,4]benzodiazepin-6-one, MITOGEN-ACTIVATED PROTEIN KINASE 7 | 著者 | Elkins, J.M, Wang, J, Vollmar, M, Mahajan, P, Savitsky, P, Deng, X, Gray, N.S, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A, Knapp, S. | 登録日 | 2012-09-03 | 公開日 | 2012-09-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor. J.Med.Chem., 56, 2013
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3NFS
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![BU of 3nfs by Molmil](/molmil-images/mine/3nfs) | Crystal structure the Fab fragment of therapeutic antibody daclizumab | 分子名称: | Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab | 著者 | Yang, H, Wang, J, Du, J, Zhong, C, Guo, Y, Ding, J. | 登録日 | 2010-06-10 | 公開日 | 2010-09-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis of immunosuppression by the therapeutic antibody daclizumab Cell Res., 20, 2010
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4BYG
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![BU of 4byg by Molmil](/molmil-images/mine/4byg) | ATPase crystal structure | 分子名称: | COPPER EFFLUX ATPASE, MAGNESIUM ION, POLYETHYLENE GLYCOL (N=34), ... | 著者 | Mattle, D, Drachmann, N.D, Liu, X.Y, Pedersen, B.P, Morth, J.P, Wang, J, Gourdon, P, Nissen, P. | 登録日 | 2013-07-19 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Dephosphorylation of Pib-Type Cu(I)-Atpases as Studied by Metallofluoride Complexes To be Published
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1OZR
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![BU of 1ozr by Molmil](/molmil-images/mine/1ozr) | Crystal Structures of the Ferric, Ferrous and Ferrous-NO Forms of the Asp140Ala Mutant of Human Heme Oxygenase-1: Catalytic Implications | 分子名称: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lad, L, Wang, J, Li, H, Friedman, J, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2003-04-09 | 公開日 | 2003-08-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications J.Mol.Biol., 330, 2003
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3J32
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![BU of 3j32 by Molmil](/molmil-images/mine/3j32) | An asymmetric unit map from electron cryo-microscopy of Haliotis diversicolor molluscan hemocyanin isoform 1 (HdH1) | 分子名称: | Hemocyanin isoform 1 | 著者 | Zhang, Q, Dai, X, Cong, Y, Zhang, J, Chen, D.-H, Dougherty, M, Wang, J, Ludtke, S, Schmid, M.F, Chiu, W. | 登録日 | 2013-02-20 | 公開日 | 2013-04-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Cryo-EM structure of a molluscan hemocyanin suggests its allosteric mechanism. Structure, 21, 2013
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1OZL
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![BU of 1ozl by Molmil](/molmil-images/mine/1ozl) | Crystal Structures of the Ferric, Ferrous, and Ferrous-NO Forms of the Asp140Ala Mutant of Human Heme Oxygenase-1: Catalytic Implications | 分子名称: | Heme oxygenase 1, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lad, L, Wang, J, Li, H, Friedman, J, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2003-04-09 | 公開日 | 2003-08-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications J.Mol.Biol., 330, 2003
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1OZW
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![BU of 1ozw by Molmil](/molmil-images/mine/1ozw) | Crystal Structures of the Ferric, Ferrous and Ferrous-NO Forms of the Asp140Ala Mutant of Human Heme Oxygenase-1: Catalytic Implications | 分子名称: | Heme oxygenase 1, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lad, L, Wang, J, Li, H, Friedman, J, Ortiz de Montellano, P.R, Poulos, T.L. | 登録日 | 2003-04-09 | 公開日 | 2003-08-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications J.Mol.Biol., 330, 2003
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5WTH
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![BU of 5wth by Molmil](/molmil-images/mine/5wth) | Cryo-EM structure for Hepatitis A virus complexed with FAB | 分子名称: | FAB Heavy Chain, FAB Light Chain, Polyprotein, ... | 著者 | Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Walter, T.S, Wang, J, Fry, E.E, Stuart, D.I, Rao, Z. | 登録日 | 2016-12-12 | 公開日 | 2017-01-25 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5WTF
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![BU of 5wtf by Molmil](/molmil-images/mine/5wtf) | Cryo-EM structure for Hepatitis A virus empty particle | 分子名称: | VP0, VP1, VP3 | 著者 | Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Walter, T.S, Wang, J, Fry, E.E, Stuart, D.I, Rao, Z. | 登録日 | 2016-12-11 | 公開日 | 2017-01-25 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1FXQ
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![BU of 1fxq by Molmil](/molmil-images/mine/1fxq) | AQUIFEX AEOLICUS KDO8P SYNTHASE IN COMPLEX WITH PEP AND A5P | 分子名称: | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE, ARABINOSE-5-PHOSPHATE, PHOSPHOENOLPYRUVATE | 著者 | Duewel, H.S, Radaev, S, Wang, J, Woodard, R.W, Gatti, D.L. | 登録日 | 2000-09-26 | 公開日 | 2001-04-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Substrate and metal complexes of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus at 1.9-A resolution. Implications for the condensation mechanism. J.Biol.Chem., 276, 2001
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