5UZ0
Crystal structure of AICARFT bound to an antifolate
Summary for 5UZ0
Entry DOI | 10.2210/pdb5uz0/pdb |
Related | 5UY8 |
Descriptor | Bifunctional purine biosynthesis protein PURH, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | aicar, aicarft, amz, transferase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 267278.21 |
Authors | Atwell, S.,Wang, Y.,Fales, K.R.,Clawson, D.,Wang, J. (deposition date: 2017-02-24, release date: 2018-01-10, Last modification date: 2024-03-06) |
Primary citation | Fales, K.R.,Njoroge, F.G.,Brooks, H.B.,Thibodeaux, S.,Torrado, A.,Si, C.,Toth, J.L.,Mc Cowan, J.R.,Roth, K.D.,Thrasher, K.J.,Frimpong, K.,Lee, M.R.,Dally, R.D.,Shepherd, T.A.,Durham, T.B.,Margolis, B.J.,Wu, Z.,Wang, Y.,Atwell, S.,Wang, J.,Hui, Y.H.,Meier, T.I.,Konicek, S.A.,Geeganage, S. Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J. Med. Chem., 60:9599-9616, 2017 Cited by PubMed: 29072452DOI: 10.1021/acs.jmedchem.7b01046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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