7BUJ
 
 | | mcGAS bound with pppGpG | | 分子名称: | Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Wang, B, Su, X.D. | | 登録日 | 2020-04-07 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
Cell Rep, 32, 2020
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7BUM
 | | mcGAS bound with pGpA | | 分子名称: | ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, ... | | 著者 | Wang, B, Su, X.D. | | 登録日 | 2020-04-07 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.047 Å) | | 主引用文献 | Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
Cell Rep, 32, 2020
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7BUQ
 | | mcGAS bound with 23-cGAMP | | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | | 著者 | Wang, B, Su, X.D. | | 登録日 | 2020-04-07 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.091 Å) | | 主引用文献 | Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
Cell Rep, 32, 2020
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8J9O
 | | Cryo-EM structure of inactive FZD1 | | 分子名称: | Frizzled-1,Soluble cytochrome b562, anti-BRIL Fab Heavy Chain, anti-BRIL Fab Light Chain, ... | | 著者 | Lin, X, Xu, F. | | 登録日 | 2023-05-04 | | 公開日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
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8J9N
 | | Gq bound FZD1 in ligand-free state | | 分子名称: | Frizzled-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Lin, X, Xu, F. | | 登録日 | 2023-05-04 | | 公開日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
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8BAL
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8BBL
 | | SGL a GH20 family sulfoglycosidase | | 分子名称: | Beta-N-acetylhexosaminidase | | 著者 | Dong, M.D, Roth, C.R, Jin, Y.J. | | 登録日 | 2022-10-13 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.711 Å) | | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 2022
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2RF2
 | | HIV reverse transcriptase in complex with inhibitor 7e (NNRTI) | | 分子名称: | 5-bromo-3-(pyrrolidin-1-ylsulfonyl)-1H-indole-2-carboxamide, Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT) | | 著者 | Yan, Y, Prasad, S. | | 登録日 | 2007-09-27 | | 公開日 | 2008-01-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Bioorg.Med.Chem.Lett., 18, 2008
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7XCK
 | | Cryo-EM structure of SARS-CoV-2 Omicron RBD in complex with S309 fab (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, S309 heavy chain, S309 light chain, ... | | 著者 | Gao, G.F, Qi, J.X, Zhao, Z.N, Xie, Y.F, Liu, S. | | 登録日 | 2022-03-24 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
Nat Commun, 13, 2022
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7XCI
 | | Cryo-EM structure of SARS-CoV-2 Omicron RBD in complex with human ACE2 ectodomain (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Gao, G.F, Qi, J.X, Zhao, Z.N, Liu, S, Xie, Y.F. | | 登録日 | 2022-03-24 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
Nat Commun, 13, 2022
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7XCH
 | | Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (two-RBD-up state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Gao, G.F, Qi, J.X, Zhao, Z.N, Liu, S, Xie, Y.F. | | 登録日 | 2022-03-24 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
Nat Commun, 13, 2022
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7XCO
 | | Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with S309 fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S309 Fab heavy chain, ... | | 著者 | Gao, G.F, Qi, J.X, Zhao, Z.N, Liu, S, Xie, Y.F. | | 登録日 | 2022-03-24 | | 公開日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
Nat Commun, 13, 2022
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7YA1
 | | Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | | 登録日 | 2022-06-27 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Nat Commun, 13, 2022
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7YAD
 | | Cryo-EM structure of S309-RBD-RBD-S309 in the S309-bound Omicron spike protein (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, S309 neutralizing antibody heavy chain, S309 neutralizing antibody light chain, ... | | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, F. | | 登録日 | 2022-06-27 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Nat Commun, 13, 2022
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7Y9S
 | | Cryo-EM structure of apo SARS-CoV-2 Omicron spike protein (S-2P-GSAS) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | | 登録日 | 2022-06-26 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Nat Commun, 13, 2022
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7Y9Z
 | | Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (one-RBD-up state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Gao, G.F, Qi, J.X, Liu, S, Zhao, Z.N. | | 登録日 | 2022-06-26 | | 公開日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Nat Commun, 13, 2022
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8WKU
 | | Complex structure of MjHKU4r-CoV-1 spike RBD bound to human CD26 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4 soluble form, MjHKU4r-CoV-1 spike RBD, ... | | 著者 | Zhao, Z.N, Chai, Y, Gao, F. | | 登録日 | 2023-09-28 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Molecular basis for receptor recognition and broad host tropism for merbecovirus MjHKU4r-CoV-1.
Embo Rep., 25, 2024
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3D8X
 | | Crystal Structure of Saccharomyces cerevisiae NDPPH Dependent Thioredoxin Reductase 1 | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase 1 | | 著者 | Zhang, Z.Y, Bao, R, Yu, J, Chen, Y.X, Zhou, C.-Z. | | 登録日 | 2008-05-26 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin
Biochim.Biophys.Acta, 1794, 2009
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6IWK
 | | The Structure of Maltooligosaccharide-forming Amylase from Pseudomonas saccharophila STB07 | | 分子名称: | CALCIUM ION, GLYCEROL, Glucan 1,4-alpha-maltotetraohydrolase | | 著者 | Li, Z.F, Ban, X.F, Zhang, Z.Q, Li, C.M, Gu, Z.B, Jin, T.C, Li, Y.L, Shang, Y.H. | | 登録日 | 2018-12-05 | | 公開日 | 2019-12-11 | | 最終更新日 | 2021-03-31 | | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | | 主引用文献 | Structure of maltotetraose-forming amylase from Pseudomonas saccharophila STB07 provides insights into its product specificity.
Int.J.Biol.Macromol., 154, 2020
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6JQB
 | | The structure of maltooligosaccharide-forming amylase from Pseudomonas saccharophila STB07 with pseudo-maltoheptaose | | 分子名称: | 1,2-ETHANEDIOL, ACARBOSE DERIVED HEPTASACCHARIDE, CALCIUM ION, ... | | 著者 | Li, Z.F, Ban, X.F, Zhang, Z.Q, Li, C.M, Gu, Z.B, Jin, T.C, Li, Y.L, Shang, Y.H. | | 登録日 | 2019-03-30 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.101 Å) | | 主引用文献 | Structure of maltotetraose-forming amylase from Pseudomonas saccharophila STB07 provides insights into its product specificity.
Int.J.Biol.Macromol., 154, 2020
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4M84
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7FAJ
 | | CARM1 bound with compound 43 | | 分子名称: | Histone-arginine methyltransferase CARM1, N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-phenylazanyl-pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine | | 著者 | Cao, D.Y, Li, J, Xiong, B. | | 登録日 | 2021-07-06 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2450726 Å) | | 主引用文献 | Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.
J.Med.Chem., 64, 2021
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7FAI
 | | CARM1 bound with compound 9 | | 分子名称: | Histone-arginine methyltransferase CARM1, N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine | | 著者 | Cao, D.Y, Li, J, Xiong, B. | | 登録日 | 2021-07-06 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.09749269 Å) | | 主引用文献 | Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.
J.Med.Chem., 64, 2021
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2Q8O
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5H4I
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