7FAI

CARM1 bound with compound 9

Summary for 7FAI

Entry DOI	10.2210/pdb7fai/pdb
Descriptor	Histone-arginine methyltransferase CARM1, N'-[[3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methyl-6-(oxan-4-ylamino)pyrimidin-2-yl]phenyl]methyl]-N-methyl-ethane-1,2-diamine (3 entities in total)
Functional Keywords	histone-arginine methyltransferase carm1, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	154716.70
Authors	Cao, D.Y.,Li, J.,Xiong, B. (deposition date: 2021-07-06, release date: 2021-11-24, Last modification date: 2023-11-29)
Primary citation	Zhang, Z.,Guo, Z.,Xu, X.,Cao, D.,Yang, H.,Li, Y.,Shi, Q.,Du, Z.,Guo, X.,Wang, X.,Chen, D.,Zhang, Y.,Chen, L.,Zhou, K.,Li, J.,Geng, M.,Huang, X.,Xiong, B. Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy. J.Med.Chem., 64:16650-16674, 2021 Cited by PubMed: 34781683 DOI: 10.1021/acs.jmedchem.1c01308 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09749259173 Å)

Structure validation