7XCH

Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (two-RBD-up state)

Summary for 7XCH

• Entry DOI: 10.2210/pdb7xch/pdb
• EMDB information: 33120
• Descriptor: Spike glycoprotein, Processed angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 5
• Total formula weight: 568197.64

Authors

Gao, G.F.,Qi, J.X.,Zhao, Z.N.,Liu, S.,Xie, Y.F. (deposition date: 2022-03-24, release date: 2022-08-31, Last modification date: 2025-06-25)

• Primary citation: Zhao, Z.,Zhou, J.,Tian, M.,Huang, M.,Liu, S.,Xie, Y.,Han, P.,Bai, C.,Han, P.,Zheng, A.,Fu, L.,Gao, Y.,Peng, Q.,Li, Y.,Chai, Y.,Zhang, Z.,Zhao, X.,Song, H.,Qi, J.,Wang, Q.,Wang, P.,Gao, G.F.; Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape; Nat Commun, 13:4958-, 2022; DOI: 10.1038/s41467-022-32665-7

Experimental method

ELECTRON MICROSCOPY (3.4 Å)