3BXU
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5DO4
| Thrombin-RNA aptamer complex | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2015-09-10 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.859 Å) | 主引用文献 | Evoking picomolar binding in RNA by a single phosphorodithioate linkage. Nucleic Acids Res., 44, 2016
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5AYW
| Structure of a membrane complex | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | 著者 | Huang, Y, Han, L, Zheng, J. | 登録日 | 2015-09-14 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.555 Å) | 主引用文献 | Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins Nat.Struct.Mol.Biol., 23, 2016
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6DD6
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7BFZ
| X-ray structure of human prostate-specific membrane antigen(PSMA) in complex with a inhibitor Glu-490 | 分子名称: | (((S)-1-carboxy-5-((E)-2-cyano-3-(5-(1-(3-methoxy-3-oxopropyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)acrylamido)pentyl)carbamoyl)-L-glutamic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Rakhimbekova, A, Motlova, L, Barinka, C. | 登録日 | 2021-01-05 | 公開日 | 2021-08-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging. Nat Commun, 12, 2021
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5DK3
| Crystal Structure of Pembrolizumab, a full length IgG4 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, ... | 著者 | Scapin, G, Prosise, W, Reichert, P. | 登録日 | 2015-09-02 | 公開日 | 2015-11-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab. Nat.Struct.Mol.Biol., 22, 2015
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2ZGC
| Crystal Structure of Active Human Granzyme M | 分子名称: | Granzyme M, SULFATE ION | 著者 | Wu, L.F, Wang, L, Hua, G.Q, Liu, K, Zhai, Y.J, Sun, F, Fan, Z.S. | 登録日 | 2008-01-21 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M J.Immunol., 183, 2009
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8ZCJ
| Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex | 分子名称: | 004-DTR-LYS-TYR-PHA-HYP, Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-29 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
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6DB3
| JAK3 with Cyanamide CP23 | 分子名称: | Tyrosine-protein kinase JAK3, [(1S)-1-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | 著者 | Vajdos, F.F. | 登録日 | 2018-05-02 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J. Med. Chem., 61, 2018
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6DUD
| JAK3 with cyanamide CP12 | 分子名称: | N-[(1S)-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]imidoformamide, SULFATE ION, Tyrosine-protein kinase JAK3 | 著者 | Vajdos, F.F. | 登録日 | 2018-06-20 | 公開日 | 2018-11-28 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J. Med. Chem., 61, 2018
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8IK0
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6DB4
| JAK3 with Cyanamide CP34 | 分子名称: | N-[(1S)-6-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]imidoformamide, Tyrosine-protein kinase JAK3 | 著者 | Vajdos, F.F. | 登録日 | 2018-05-02 | 公開日 | 2018-11-28 | 最終更新日 | 2019-05-01 | 実験手法 | X-RAY DIFFRACTION (1.662 Å) | 主引用文献 | Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J. Med. Chem., 61, 2018
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6DA4
| JAK3 with Cyanamide CP10 | 分子名称: | (Z)-1-{2,2-difluoro-6-[5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-4H-1,4-benzoxazin-4-yl}methanimine, Tyrosine-protein kinase JAK3 | 著者 | Vajdos, F.F. | 登録日 | 2018-05-01 | 公開日 | 2018-11-28 | 最終更新日 | 2019-05-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J. Med. Chem., 61, 2018
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6NZR
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6NZQ
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6NZF
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6NZH
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6NZE
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6NZP
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4HXX
| Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1 | 分子名称: | (1R)-N~2~-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N~1~-(4-phenylbutyl)ethane-1,2-diamine, COBALT (II) ION, Methionine aminopeptidase 1, ... | 著者 | Gabelli, S.B, Zhang, F, Liu, J, Amzel, L.M. | 登録日 | 2012-11-12 | 公開日 | 2013-04-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg.Med.Chem., 21, 2013
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6IO4
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6IOJ
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7LRD
| Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model | 分子名称: | (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one, MAGNESIUM ION, MANGANESE (II) ION, ... | 著者 | Fuller, J.R, Garvie, C.W, Lemke, C.T. | 登録日 | 2021-02-16 | 公開日 | 2021-06-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun, 12, 2021
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7LRE
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7LRC
| Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement | 分子名称: | (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one, MAGNESIUM ION, MANGANESE (II) ION, ... | 著者 | Fuller, J.R, Garvie, C.W, Lemke, C.T. | 登録日 | 2021-02-16 | 公開日 | 2021-06-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun, 12, 2021
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