8D4Z
Crystal structure of USP7 in complex with allosteric inhibitor FX1-3763
Summary for 8D4Z
Entry DOI | 10.2210/pdb8d4z/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, 1-({(7M)-7-[1-(azetidin-3-yl)-6-chloro-1,2,3,4-tetrahydroquinolin-8-yl]thieno[3,2-b]pyridin-2-yl}methyl)pyrrolidine-2,5-dione, GLYCEROL, ... (4 entities in total) |
Functional Keywords | usp7, allosteric, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 85129.03 |
Authors | |
Primary citation | Futran, A.S.,Lu, T.,Amberg-Johnson, K.,Xu, J.,Yang, X.,He, S.,Boyce, S.,Bell, J.,Pelletier, R.,Suzuki, T.,Huang, X.,Qian, H.,Fang, L.,Xing, L.,Xu, Z.,Kurtz, S.E.,Tyner, J.W.,Tang, W.,Guo, T.,Akinsanya, K.,Madge, D.,Jensen, K. Novel USP7 inhibitors demonstrate potent anti-cancer activity in models of AML, synergy with BCL2 inhibition, and a differentiated mechanism of action To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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