8D4Z
Crystal structure of USP7 in complex with allosteric inhibitor FX1-3763
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 361 | 42051.5 | 2 | UniProt (Q93009) Pfam (PF00443) | Homo sapiens (human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | C, E (A, B) | 1-({(7M)-7-[1-(azetidin-3-yl)-6-chloro-1,2,3,4-tetrahydroquinolin-8-yl]thieno[3,2-b]pyridin-2-yl}methyl)pyrrolidine-2,5-dione | non-polymer | 467.0 | 2 | Chemie (QBL) | |||
| 3 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, B: 207 - 560 (UniProt: Q93009)
| PDB | External Database | Details |
|---|---|---|
| Met 206 | - | initiating methionine |
| His 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
| His 564 | - | expression tag |
| His 565 | - | expression tag |
| His 566 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84103.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1026.1 | |
| All* | Total formula weight | 85129.0 |
