8D4Z

Crystal structure of USP7 in complex with allosteric inhibitor FX1-3763

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ubiquitin carboxyl-terminal hydrolase 7	polymer	361	42051.5	2	UniProt (Q93009) Pfam (PF00443) In PDB	Homo sapiens (human)	Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7
2	A, B	1-({(7M)-7-[1-(azetidin-3-yl)-6-chloro-1,2,3,4-tetrahydroquinolin-8-yl]thieno[3,2-b]pyridin-2-yl}methyl)pyrrolidine-2,5-dione	non-polymer		467.0	2	Chemie (QBL)
3	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	101	Chemie (HOH)

Sequence modifications

A, B: 207 - 560 (UniProt: Q93009)

PDB	External Database	Details
Met 206	-	initiating methionine
His 561	-	expression tag
His 562	-	expression tag
His 563	-	expression tag
His 564	-	expression tag
His 565	-	expression tag
His 566	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84103.0
Non-Polymers*	Number of molecules	3
	Total formula weight	1026.1
All*	Total formula weight	85129.0

*Water molecules are not included.