3U9N

X-ray crystal structure of compound 1 bound to human CHK1 kinase domain

Summary for 3U9N

• Entry DOI: 10.2210/pdb3u9n/pdb
• Related: 3PA3 3PA4 3PA5
• Descriptor: Serine/threonine-protein kinase Chk1, 2-(2,3-dihydro-1-benzofuran-5-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide (3 entities in total)
• Functional Keywords: protein kinase domain, atpase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O14757
• Total number of polymer chains: 1
• Total formula weight: 31861.73

Authors

Fischmann, T.O. (deposition date: 2011-10-19, release date: 2012-01-25, Last modification date: 2024-02-28)

• Primary citation: Huang, X.,Cheng, C.C.,Fischmann, T.O.,Duca, J.S.,Yang, X.,Richards, M.,Shipps Jr., G.W.; Discovery of a Novel Series of CHK1 Kinase Inhibitors with Distinctive Hinge Binding Mode; ACS MED.CHEM.LETT., 2012

Experimental method

X-RAY DIFFRACTION (1.85 Å)