3SWW
 
 | | Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one, ... | | 著者 | Klei, H.E. | | 登録日 | 2011-07-14 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site.
Bioorg.Med.Chem.Lett., 21, 2011
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7FAS
 | | VAR2CSA 3D7 ectodomain core region | | 分子名称: | Erythrocyte membrane protein 1, PfEMP1 | | 著者 | Wang, L, Zhaoning, W. | | 登録日 | 2021-07-07 | | 公開日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum.
Cell Discov, 7, 2021
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4EFG
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4EXZ
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4EDE
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4EEJ
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4RUU
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8JMX
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4GKC
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7FAP
 | | Structure of VAR2CSA-CSA 3D7 | | 分子名称: | 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-3)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, Erythrocyte membrane protein 1, PfEMP1 | | 著者 | Wang, L, Wang, Z. | | 登録日 | 2021-07-07 | | 公開日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum.
Cell Discov, 7, 2021
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7DIE
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7WRG
 | | Crystal structure of full-length kinesin-3 KLP-6 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein, MAGNESIUM ION | | 著者 | Wang, W.J, Ren, J.Q, Song, W.Y, Feng, W. | | 登録日 | 2022-01-26 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | | 主引用文献 | The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.
Nat Commun, 13, 2022
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7DWO
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7DWN
 | | Crystal structure of Vibrio fischeri DarR in complex with DNA reveals the transcriptional activation mechanism of LTTR family members | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Predicted DNA-binding transcriptional regulator | | 著者 | Wang, W.W, Wu, H, He, J.H, Yu, F. | | 登録日 | 2021-01-17 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Crystal structure details of Vibrio fischeri DarR and mutant DarR-M202I from LTTR family reveals their activation mechanism.
Int.J.Biol.Macromol., 183, 2021
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7XZ4
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8BP8
 | | SPA of Trypsin untreated Rotavirus TLP spike | | 分子名称: | CALCIUM ION, Inner capsid protein VP2, Intermediate capsid protein VP6, ... | | 著者 | Shah, P.N.M, Stuart, D.I. | | 登録日 | 2022-11-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography.
Cell Host Microbe, 31, 2023
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6Z5L
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8X5D
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7U6F
 | | Mouse retromer (VPS26/VPS35/VPS29) heterotrimers | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... | | 著者 | Kendall, A.K, Chandra, M, Jackson, L.P. | | 登録日 | 2022-03-04 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Improved mammalian retromer cryo-EM structures reveal a new assembly interface.
J.Biol.Chem., 298, 2022
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5IJO
 | | Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) | | 分子名称: | Nuclear pore complex protein Nup155, Nuclear pore complex protein Nup205, Nuclear pore complex protein Nup93, ... | | 著者 | Kosinski, J, Mosalaganti, S, von Appen, A, Beck, M. | | 登録日 | 2016-03-02 | | 公開日 | 2016-04-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (21.4 Å) | | 主引用文献 | Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
Science, 352, 2016
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2N0A
 | | Atomic-resolution structure of alpha-synuclein fibrils | | 分子名称: | Alpha-synuclein | | 著者 | Tuttle, M.D, Comellas, G, Nieuwkoop, A.J, Covell, D.J, Berthold, D.A, Kloepper, K.D, Courtney, J.M, Kim, J.K, Schwieters, C.D, Lee, V.M, George, J.M, Rienstra, C.M. | | 登録日 | 2015-03-04 | | 公開日 | 2016-03-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein.
Nat.Struct.Mol.Biol., 23, 2016
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5IJN
 | | Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205) | | 分子名称: | NUCLEAR PORE COMPLEX PROTEIN NUP155, NUCLEAR PORE COMPLEX PROTEIN NUP205, NUCLEAR PORE COMPLEX PROTEIN NUP54, ... | | 著者 | Kosinski, J, Mosalaganti, S, von Appen, A, Beck, M. | | 登録日 | 2016-03-02 | | 公開日 | 2016-04-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (21.4 Å) | | 主引用文献 | Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
Science, 352, 2016
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8COA
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8CO6
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7VMU
 | | Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody | | 分子名称: | Spike protein S1, scFv E4 | | 著者 | Guo, Y, Wang, W, Jiao, P, Yang, H, Rao, Z, Cheng, G. | | 登録日 | 2021-10-09 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants.
Cell Biosci, 12, 2022
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