7CJM
| SARS CoV-2 PLpro in complex with GRL0617 | 分子名称: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, ZINC ION | 著者 | Fu, Z, Huang, H. | 登録日 | 2020-07-11 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery. Nat Commun, 12, 2021
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6UPV
| Alpha-E-catenin ABD-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Mei, L, Alushin, G.M. | 登録日 | 2019-10-18 | 公開日 | 2020-09-30 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular mechanism for direct actin force-sensing by alpha-catenin. Elife, 9, 2020
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1F2K
| CRYSTAL STRUCTURE OF ACANTHAMOEBA CASTELLANII PROFILIN II, CUBIC CRYSTAL FORM | 分子名称: | PROFILIN II | 著者 | Fedorov, A.A, Shi, W, Mahoney, N, Kaiser, D.A, Almo, S.C. | 登録日 | 2000-05-26 | 公開日 | 2000-06-08 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Comparative Structural Analysis of Profilins To be Published
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6UPW
| Metavinculin ABD-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Mei, L, Alushin, G.M. | 登録日 | 2019-10-18 | 公開日 | 2020-09-30 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular mechanism for direct actin force-sensing by alpha-catenin. Elife, 9, 2020
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7BW6
| Varicella-zoster virus capsid | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | 著者 | Wang, P.Y, Qi, J.X, Liu, C.C, Sun, J.Q. | 登録日 | 2020-04-13 | 公開日 | 2020-09-23 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structure of the varicella-zoster virus A-capsid. Nat Commun, 11, 2020
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1G5U
| LATEX PROFILIN HEVB8 | 分子名称: | PROFILIN, SODIUM ION | 著者 | Fedorov, A.A, Fedorov, E.V, Ganglberger, E, Breiteneder, H, Almo, S.C. | 登録日 | 2000-11-02 | 公開日 | 2000-11-22 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A Comparative Structural Analysis of Allergen Profilins HEVB8 and BETV2 To be Published
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4J51
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5KJ0
| CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH DB-1-264-2 | 分子名称: | 1,2-ETHANEDIOL, 4-[[(7~{R})-8-cyclopentyl-7-ethyl-5-methyl-6-oxidanylidene-7~{H}-pteridin-2-yl]-methyl-amino]-3-methoxy-~{N}-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 4 | 著者 | Zhu, J.-Y, Ember, S.W, Schonbrunn, E. | 登録日 | 2016-06-17 | 公開日 | 2017-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET. ChemMedChem, 11, 2016
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6WQ1
| Eukaryotic LanCL2 protein | 分子名称: | LanC-like protein 2, ZINC ION | 著者 | Nair, S.K, Garg, N. | 登録日 | 2020-04-28 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | 主引用文献 | LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome. Cell, 184, 2021
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7FD2
| Cryo-EM structure of an alphavirus, Getah virus | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Liu, Z, Liu, C, Wang, A. | 登録日 | 2021-07-15 | 公開日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structure of infective Getah virus at 2.8 angstrom resolution determined by cryo-electron microscopy. Cell Discov, 8, 2022
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3LM5
| Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Serine/threonine-protein kinase 17B | 著者 | Ugochukwu, E, Soundararajan, M, Rellos, P, Fedorov, O, Phillips, C, Wang, J, Hapka, E, Filippakopoulos, P, Chaikuad, A, Pike, A.C.W, Carpenter, L, Vollmar, M, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-01-29 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63, 2020
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6F57
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7CAL
| Cryo-EM Structure of the Hyperpolarization-Activated Inwardly Rectifying Potassium Channel KAT1 from Arabidopsis | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Potassium channel KAT1 | 著者 | Li, S.Y, Yang, F, Sun, D.M, Zhang, Y, Zhang, M.G, Zhou, P, Liu, S.L, Zhang, Y.N, Zhang, L.H, Tian, C.L. | 登録日 | 2020-06-09 | 公開日 | 2020-07-29 | 最終更新日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis. Cell Res., 30, 2020
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6MDD
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6AGL
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6AGM
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7E39
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7E3B
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7E3C
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6MDC
| Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 1 SHP389 | 分子名称: | 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclopropylamino)pyridin-4-yl]-5-methyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Fodor, M, Stams, T. | 登録日 | 2018-09-04 | 公開日 | 2019-02-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
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6MX8
| Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib | 分子名称: | 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine, ALK tyrosine kinase receptor | 著者 | Dougan, D.R, Zhou, T. | 登録日 | 2018-10-30 | 公開日 | 2018-12-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase. J. Med. Chem., 59, 2016
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5YJ6
| The exoglucanase CelS from Clostridium thermocellum | 分子名称: | 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane-1,38-diol, Dockerin type I repeat-containing protein | 著者 | Liu, Y.J, Liu, S.Y, Dong, S, Li, R.M, Feng, Y.G, Cui, Q. | 登録日 | 2017-10-09 | 公開日 | 2018-01-31 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Determination of the native features of the exoglucanase Cel48S from Clostridium thermocellum Biotechnol Biofuels, 11, 2018
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8T9F
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8T9H
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7LGS
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