6D80
| Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri bound to saposin | 分子名称: | CALCIUM ION, Mitochondrial calcium uniporter, Saposin A | 著者 | Nguyen, N.X, Armache, J.-P, Cheng, Y, Bai, X.C. | 登録日 | 2018-04-25 | 公開日 | 2018-07-11 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature, 559, 2018
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6D7W
| Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution | 分子名称: | CALCIUM ION, Mitochondrial calcium uniporter | 著者 | Nguyen, N.X, Armache, J.-P, Cheng, Y, Bai, X.C. | 登録日 | 2018-04-25 | 公開日 | 2018-07-11 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature, 559, 2018
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5KDT
| Structure of the human GluN1/GluN2A LBD in complex with GNE0723 | 分子名称: | (1~{R},2~{R})-2-[7-[[5-chloranyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-5-oxidanylidene-2-(trifluoromethyl)-[1,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropane-1-carbonitrile, ACETATE ION, GLUTAMIC ACID, ... | 著者 | Wallweber, H.J.A, Lupardus, P.J. | 登録日 | 2016-06-08 | 公開日 | 2016-07-13 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J. Med. Chem., 59, 2016
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4XZ7
| Crystal structure of a TGase | 分子名称: | Putative uncharacterized protein | 著者 | Yu, J, Ge, J, Yang, M. | 登録日 | 2015-02-04 | 公開日 | 2015-06-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Functional and Structural Characterization of the Antiphagocytic Properties of a Novel Transglutaminase from Streptococcus suis J.Biol.Chem., 290, 2015
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6IIK
| USP14 catalytic domain with IU1 | 分子名称: | 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one, Ubiquitin carboxyl-terminal hydrolase 14 | 著者 | Mei, Z.Q, Wang, Y.W, He, W, Wang, F. | 登録日 | 2018-10-06 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
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5JD0
| crystal structure of ARAP3 RhoGAP domain | 分子名称: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | 著者 | Bao, H, Li, F, Wu, J, Shi, Y. | 登録日 | 2016-04-15 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3 J.Biol.Chem., 291, 2016
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6IIN
| USP14 catalytic domain with IU1-248 | 分子名称: | 4-{3-[(4-hydroxypiperidin-1-yl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl}benzonitrile, Ubiquitin carboxyl-terminal hydrolase 14 | 著者 | Mei, Z.Q, Wang, J.W, Wang, F, Wang, Y.W. | 登録日 | 2018-10-07 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
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6IIM
| USP14 catalytic domain with IU1-206 | 分子名称: | 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(4-hydroxypiperidin-1-yl)ethan-1-one, Ubiquitin carboxyl-terminal hydrolase 14 | 著者 | Mei, Z.Q, Wang, J.W, Wang, F, Wang, Y.W. | 登録日 | 2018-10-07 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
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6DF4
| TAF1-BD2 in complex with Cpd8 (6-(but-3-en-1-yl)-4-(3-(morpholine-4-carbonyl)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one) | 分子名称: | 6-(but-3-en-1-yl)-4-[3-(morpholine-4-carbonyl)phenyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one, Transcription initiation factor TFIID subunit | 著者 | Murray, J.M, Tang, Y. | 登録日 | 2018-05-14 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J. Med. Chem., 61, 2018
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6WU8
| Structure of human SHP2 in complex with inhibitor IACS-13909 | 分子名称: | 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Leonard, P.G, Joseph, S, Rodenberger, A. | 登録日 | 2020-05-04 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res., 80, 2020
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6XPE
| Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation | 分子名称: | ZINC ION, Zinc transporter 8 | 著者 | Bai, X.C, Xue, J, Jiang, Y.X. | 登録日 | 2020-07-08 | 公開日 | 2020-08-05 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife, 9, 2020
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6XTI
| NMR solution structure of class IV lasso peptide felipeptin A2 from Amycolatopsis sp. YIM10 | 分子名称: | Felipeptin A2 | 著者 | Madland, E, Aachmann, F.L, Guerrero-Garzon, J.F, Zotchev, S.B, Courtade, G. | 登録日 | 2020-01-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. Iscience, 23, 2020
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6XPF
| Cryo-EM structure of human ZnT8 WT, in the absence of zinc, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation | 分子名称: | ZINC ION, Zinc transporter 8 | 著者 | Bai, X.C, Xue, J, Jiang, Y.X. | 登録日 | 2020-07-08 | 公開日 | 2020-08-05 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife, 9, 2020
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6XPD
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6XTH
| NMR solution structure of class IV lasso peptide felipeptin A1 from Amycolatopsis sp. YIM10 | 分子名称: | Felipeptin A1 | 著者 | Madland, E, Guerrero-Garzon, J.F, Zotchev, S.B, Aachmann, F.L, Courtade, G. | 登録日 | 2020-01-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. Iscience, 23, 2020
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5J9K
| Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) in complex with rice D53 repressor EAR peptide motif | 分子名称: | Protein TPR1, ZINC ION, rice D53 peptide 794-808 | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-10 | 公開日 | 2017-07-05 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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5JGC
| Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A, L130A, L179A and I195A mutant | 分子名称: | Protein TPR1, ZINC ION | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-20 | 公開日 | 2017-07-05 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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5JHP
| Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L179A and I195A mutant in complex with rice D53 repressor EAR peptide motif | 分子名称: | Protein TPR1, The rice D53 EAR peptide (794-808) | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-21 | 公開日 | 2017-07-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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5TIJ
| Structure of Human Enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonate (purified enantiomer) | 分子名称: | ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid, Gamma-enolase, MAGNESIUM ION | 著者 | Leonard, P.G, Muller, F.L. | 登録日 | 2016-10-03 | 公開日 | 2017-10-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.634 Å) | 主引用文献 | Eradication of ENO1-deleted Glioblastoma through Collateral Lethality Biorxiv, 2019
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6VN7
| Cryo-EM structure of an activated VIP1 receptor-G protein complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. | 登録日 | 2020-01-29 | 公開日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun, 11, 2020
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7X31
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7X4B
| Crystal Structure of An Anti-CRISPR Protein | 分子名称: | Anti-CRISPR protein (AcrIIC1), SULFATE ION | 著者 | Hu, J, Zhang, S, Gao, J.Y, Liu, X, Liu, J. | 登録日 | 2022-03-02 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1. Nat Commun, 13, 2022
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6DF7
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6O84
| Cryo-EM structure of OTOP3 from xenopus tropicalis | 分子名称: | LOC100127796 protein,LOC100127796 protein,OTOP3,LOC100127796 protein,LOC100127796 protein | 著者 | Chen, Q.F, Bai, X.C, Jiang, Y.X. | 登録日 | 2019-03-08 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Structural and functional characterization of an otopetrin family proton channel. Elife, 8, 2019
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6FBV
| Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Das, K, Lin, W, Ebright, E. | 登録日 | 2017-12-19 | 公開日 | 2018-02-28 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
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