5UHG

Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-AAP1 and Rifampin

Summary for 5UHG

• Entry DOI: 10.2210/pdb5uhg/pdb
• Related: 5UH6 5UH7 5UH8 5UH9 5UHA 5UHB 5UHC 5UHD 5UHE 5UHF
• Descriptor: DNA-directed RNA polymerase subunit alpha, MAGNESIUM ION, Nalpha-(benzenecarbonyl)-N-(2-methylphenyl)-D-phenylalaninamide, ... (11 entities in total)
• Functional Keywords: rna polymerase complex, transcription, dna, rna, transcription-dna-rna complex, antibiotic, transcription/dna/rna
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Cellular location: Cytoplasm : P9WGI1
• Total number of polymer chains: 8
• Total formula weight: 435643.09

Authors

Lin, W.,Das, K.,Feng, Y.,Ebright, R.H. (deposition date: 2017-01-11, release date: 2017-04-12, Last modification date: 2017-11-22)

• Primary citation: Lin, W.,Mandal, S.,Degen, D.,Liu, Y.,Ebright, Y.W.,Li, S.,Feng, Y.,Zhang, Y.,Mandal, S.,Jiang, Y.,Liu, S.,Gigliotti, M.,Talaue, M.,Connell, N.,Das, K.,Arnold, E.,Ebright, R.H.; Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.; Mol. Cell, 66:169-179.e8, 2017; PubMed: 28392175; DOI: 10.1016/j.molcel.2017.03.001

Experimental method

X-RAY DIFFRACTION (3.971 Å)