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4FF5
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BU of 4ff5 by Molmil
Structure basis of a novel virulence factor GHIP a glycosyl hydrolase 25 of Streptococcus pneumoniae participating in host cell invasion
分子名称: 1,2-ETHANEDIOL, Glycosyl hydrolase 25
著者Wang, D.
登録日2012-05-31
公開日2013-07-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion.
Plos One, 8, 2013
3UAI
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BU of 3uai by Molmil
Structure of the Shq1-Cbf5-Nop10-Gar1 complex from Saccharomyces cerevisiae
分子名称: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 3, H/ACA ribonucleoprotein complex subunit 4, ...
著者Ye, K.
登録日2011-10-21
公開日2011-12-14
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita
Embo J., 30, 2011
4EMP
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BU of 4emp by Molmil
Crystal structure of the mutant of ClpP E137A from Staphylococcus aureus
分子名称: ATP-dependent Clp protease proteolytic subunit
著者Ye, F, Zhang, J, Liu, H, Luo, C, Yang, C.-G.
登録日2012-04-12
公開日2013-04-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease
J.Biol.Chem., 288, 2013
5O6E
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BU of 5o6e by Molmil
Structure of ScPif1 in complex with TTTGGGTT and ADP-AlF4
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, CHLORIDE ION, ...
著者Lu, K.Y, Chen, W.F, Rety, S, Liu, N.N, Xu, X.G.
登録日2017-06-06
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.345 Å)
主引用文献Insights into the structural and mechanistic basis of multifunctional S. cerevisiae Pif1p helicase.
Nucleic Acids Res., 46, 2018
5V7V
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BU of 5v7v by Molmil
Cryo-EM structure of ERAD-associated E3 ubiquitin-protein ligase component HRD3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ERAD-associated E3 ubiquitin-protein ligase component HRD3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Mi, W, Schoebel, S, Stein, A, Rapoport, T.A, Liao, M.
登録日2017-03-20
公開日2017-08-16
最終更新日2025-06-04
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.
Nature, 548, 2017
4XFV
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BU of 4xfv by Molmil
Crystal Structure of Elp2
分子名称: Elongator complex protein 2
著者Lin, Z, Dong, C, Long, J, Shen, Y.
登録日2014-12-29
公開日2015-05-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The elp2 subunit is essential for elongator complex assembly and functional regulation
Structure, 23, 2015
3L0V
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BU of 3l0v by Molmil
Crystal structure of catalytic domain of TACE with the first hydantoin inhibitor occupying the S1' pocket
分子名称: (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-methylimidazolidine-2,4-dione, Disintegrin and metalloproteinase domain-containing protein 17, ZINC ION
著者Orth, P.
登録日2009-12-10
公開日2010-03-02
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery and SAR of hydantoin TACE inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
7YRZ
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BU of 7yrz by Molmil
Crystal structure of HCoV 229E main protease in complex with PF07321332
分子名称: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase
著者Zhou, Y.R, Zeng, P, Zhou, X.L, Lin, C, Zhang, J, Yin, X.S, Li, J.
登録日2022-08-11
公開日2023-08-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332.
Biochem.Biophys.Res.Commun., 657, 2023
3IKA
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BU of 3ika by Molmil
Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002
分子名称: Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
著者Yun, C.-H, Eck, M.J.
登録日2009-08-05
公開日2010-01-12
最終更新日2024-11-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Nature, 462, 2009
7LYK
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BU of 7lyk by Molmil
South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 2-RBD-up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2021-03-07
公開日2021-03-31
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Science, 373, 2021
7XAZ
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BU of 7xaz by Molmil
Crystal structure of Omicron BA.1.1 RBD complexed with hACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Liao, H, Meng, Y, Li, W.
登録日2022-03-19
公開日2022-07-06
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1.
Cell, 185, 2022
7LYQ
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BU of 7lyq by Molmil
South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2021-03-07
公開日2021-03-31
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Science, 373, 2021
7LYO
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BU of 7lyo by Molmil
South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2021-03-07
公開日2021-03-31
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Science, 373, 2021
7LYP
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BU of 7lyp by Molmil
South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2021-03-07
公開日2021-03-31
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (4.05 Å)
主引用文献Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Science, 373, 2021
7LYL
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BU of 7lyl by Molmil
South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the RBD-down conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2021-03-07
公開日2021-03-31
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Science, 373, 2021
7XB1
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BU of 7xb1 by Molmil
Crystal structure of Omicron BA.3 RBD complexed with hACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Li, W, Meng, Y, Liao, H.
登録日2022-03-19
公開日2022-07-06
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1.
Cell, 185, 2022
7LYN
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BU of 7lyn by Molmil
South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2021-03-07
公開日2021-03-31
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Science, 373, 2021
3L0T
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BU of 3l0t by Molmil
Crystal structure of catalytic domain of TACE with hydantoin inhibitor
分子名称: Disintegrin and metalloproteinase domain-containing protein 17, ISOPROPYL ALCOHOL, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ...
著者Orth, P.
登録日2009-12-10
公開日2010-03-02
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Discovery and SAR of hydantoin TACE inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
8I4Z
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BU of 8i4z by Molmil
CalA3 with hydrolysis product
分子名称: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I
著者Wang, J, Wang, Z.
登録日2023-01-21
公開日2023-02-22
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.97 Å)
主引用文献C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
8I4Y
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BU of 8i4y by Molmil
CalA3 complex structure with amidation product
分子名称: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I
著者Wang, J, Wang, Z.
登録日2023-01-21
公開日2023-02-22
最終更新日2025-04-02
実験手法ELECTRON MICROSCOPY (3.84 Å)
主引用文献C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
5V6P
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BU of 5v6p by Molmil
CryoEM structure of the ERAD-associated E3 ubiquitin-protein ligase HRD1
分子名称: ERAD-associated E3 ubiquitin-protein ligase HRD1
著者Schoebel, S, Mi, W, Stein, A, Rapoport, T.A, Liao, M.
登録日2017-03-17
公開日2017-08-16
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.
Nature, 548, 2017
5X40
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BU of 5x40 by Molmil
Structure of a CbiO dimer bound with AMPPCP
分子名称: Cobalt ABC transporter ATP-binding protein, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
著者Bao, Z, Qi, X, Wang, J, Zhang, P.
登録日2017-02-09
公開日2017-04-05
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure and mechanism of a group-I cobalt energy coupling factor transporter
Cell Res., 27, 2017
6AHF
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BU of 6ahf by Molmil
CryoEM Reconstruction of Hsp104 N728A Hexamer
分子名称: Heat shock protein 104, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Zhang, X, Zhang, L, Zhang, S.
登録日2018-08-17
公開日2019-02-13
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (6.78 Å)
主引用文献Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity.
J. Biol. Chem., 294, 2019
5X3X
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BU of 5x3x by Molmil
2.8A resolution structure of a cobalt energy-coupling factor transporter-CbiMQO
分子名称: Cobalt ABC transporter ATP-binding protein, Cobalt transport protein CbiM, Uncharacterized protein CbiQ
著者Bao, Z, Qi, X, Wang, J, Zhang, P.
登録日2017-02-09
公開日2017-04-05
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.788 Å)
主引用文献Structure and mechanism of a group-I cobalt energy coupling factor transporter
Cell Res., 27, 2017
8J5Z
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BU of 8j5z by Molmil
The cryo-EM structure of the TwOSC1 tetramer
分子名称: Terpene cyclase/mutase family member, octyl beta-D-glucopyranoside
著者Ma, X, Yuru, T, Yunfeng, L, Jiang, T.
登録日2023-04-24
公開日2023-11-01
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (4.75 Å)
主引用文献Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC.
Angew.Chem.Int.Ed.Engl., 62, 2023

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