8AKK
 
 | | Acyl-enzyme complex of imipenem bound to deacylation mutant KPC-2 (E166Q) | | 分子名称: | (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.
J.Am.Chem.Soc., 145, 2023
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8AKI
 | | Acyl-enzyme complex of ampicillin bound to deacylation mutant KPC-2 (E166Q) | | 分子名称: | (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.
J.Am.Chem.Soc., 145, 2023
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8AKJ
 | | Acyl-enzyme complex of cephalothin bound to deacylation mutant KPC-2 (E166Q) | | 分子名称: | 5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.
J.Am.Chem.Soc., 145, 2023
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8AKL
 | | Acyl-enzyme complex of meropenem bound to deacylation mutant KPC-2 (E166Q) | | 分子名称: | (2S,3R,4R)-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-3-methyl-2-[(2S,3R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.
J.Am.Chem.Soc., 145, 2023
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6D54
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7ZFR
 | | Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide bound in the reverse direction | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DP alpha chain (DPA1*02:01), MHC class II HLA-DP beta chain (DPB1*01:01), ... | | 著者 | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | | 登録日 | 2022-04-01 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes.
Immunity, 56, 2023
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6E21
 | | Joint X-ray/neutron structure of PKAc with products Sr2-ADP and phosphorylated peptide SP20 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, STRONTIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... | | 著者 | Kovalevsky, A, Gerlits, O.O, Taylor, S. | | 登録日 | 2018-07-10 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-11-06 | | 実験手法 | NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION | | 主引用文献 | Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex.
Sci Adv, 5, 2019
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6E5G
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1ZAB
 | | Crystal Structure of Mouse Cytidine Deaminase Complexed with 3-Deazauridine | | 分子名称: | 1-((2R,3R,4S,5R)-TETRAHYDRO-3,4-DIHYDROXY-5-(HYDROXYMETHYL)FURAN-2-YL)PYRIDINE-2,4(1H,3H)-DIONE, Cytidine deaminase, SULFATE ION, ... | | 著者 | Teh, A.H. | | 登録日 | 2005-04-06 | | 公開日 | 2006-04-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | The 1.48 A Resolution Crystal Structure of the Homotetrameric Cytidine Deaminase from Mouse
Biochemistry, 45, 2006
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8PKC
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6LVR
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3KCL
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3KBJ
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3KCO
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3KBN
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2DT9
 | | Crystal structure of the regulatory subunit of aspartate kinase from Thermus flavus | | 分子名称: | ACETATE ION, Aspartokinase, THREONINE | | 著者 | Yoshida, A, Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2006-07-11 | | 公開日 | 2007-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase from Thermus thermophilus
Febs J., 276, 2009
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8AHW
 | | Structure of DCS-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, Alanine racemase, GLYCEROL | | 著者 | de Chiara, C, Prosser, G, Ogrodowicz, R.W, de Carvalho, L.P.S. | | 登録日 | 2022-07-22 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis .
Acs Bio Med Chem Au, 3, 2023
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3KKX
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3KMF
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3CWH
 | | D-xylose Isomerase in complex with linear product, per-deuterated xylulose | | 分子名称: | D-XYLULOSE, HYDROXIDE ION, MAGNESIUM ION, ... | | 著者 | Kovalevsky, A.Y, Langan, P, Glusker, J.P. | | 登録日 | 2008-04-21 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | NEUTRON DIFFRACTION (2.2 Å) | | 主引用文献 | Hydrogen location in stages of an enzyme-catalyzed reaction: time-of-flight neutron structure of D-xylose isomerase with bound D-xylulose
Biochemistry, 47, 2008
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8QHN
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9G8K
 | | Structure of K+-dependent Na+-PPase from Thermotoga maritima in complex with Ca2+ and Etidronate | | 分子名称: | (1-hydroxyethane-1,1-diyl)bis(phosphonic acid), CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Vidilaseris, K, Liu, J, Goldman, A. | | 登録日 | 2024-07-23 | | 公開日 | 2025-06-04 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases
Elife, 2024
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2ZHO
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6QIX
 | | The crystal structure of Trichuris muris p43 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | | 著者 | Levy, C.W. | | 登録日 | 2019-01-21 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function.
Nat Commun, 10, 2019
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6PW8
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