8AKK
Acyl-enzyme complex of imipenem bound to deacylation mutant KPC-2 (E166Q)
Summary for 8AKK
Entry DOI | 10.2210/pdb8akk/pdb |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, Imipenem, (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, ... (6 entities in total) |
Functional Keywords | acyl-enzyme complex, antibiotic resistance, beta-lactamase, antibiotic, ligand, antimicrobial protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 31896.75 |
Authors | Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2022-07-29, release date: 2023-03-08, Last modification date: 2024-02-07) |
Primary citation | Tooke, C.L.,Hinchliffe, P.,Beer, M.,Zinovjev, K.,Colenso, C.K.,Schofield, C.J.,Mulholland, A.J.,Spencer, J. Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase. J.Am.Chem.Soc., 145:7166-7180, 2023 Cited by PubMed: 36972204DOI: 10.1021/jacs.2c12123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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