6W98
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![BU of 6w98 by Molmil](/molmil-images/mine/6w98) | Single-Particle Cryo-EM Structure of Arabinofuranosyltransferase AftD from Mycobacteria | 分子名称: | 4'-PHOSPHOPANTETHEINE, Acyl carrier protein, CALCIUM ION, ... | 著者 | Tan, Y.Z, Zhang, L, Rodrigues, J, Zheng, R.B, Giacometti, S.I, Rosario, A.L, Kloss, B, Dandey, V.P, Wei, H, Brunton, R, Raczkowski, A.M, Athayde, D, Catalao, M.J, Pimentel, M, Clarke, O.B, Lowary, T.L, Archer, M, Niederweis, M, Potter, C.S, Carragher, B, Mancia, F. | 登録日 | 2020-03-22 | 公開日 | 2020-05-13 | 最終更新日 | 2020-06-03 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria. Mol.Cell, 78, 2020
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5KC2
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![BU of 5kc2 by Molmil](/molmil-images/mine/5kc2) | Negative stain structure of Vps15/Vps34 complex | 分子名称: | Phosphatidylinositol 3-kinase VPS34, Serine/threonine-protein kinase VPS15 | 著者 | Kirsten, M.L, Zhang, L, Ohashi, Y, Perisic, O, Williams, R.L, Sachse, C. | 登録日 | 2016-06-04 | 公開日 | 2016-10-05 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (28 Å) | 主引用文献 | Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Autophagy, 12, 2016
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5KC1
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![BU of 5kc1 by Molmil](/molmil-images/mine/5kc1) | Structure of the C-terminal dimerization domain of Atg38 | 分子名称: | 1,2-ETHANEDIOL, AMMONIUM ION, Autophagy-related protein 38, ... | 著者 | Ohashi, Y, Soler, N, Garcia-Ortegon, M, Zhang, L, Perisic, O, Masson, G.R, Johnson, C.M, Williams, R.J. | 登録日 | 2016-06-04 | 公開日 | 2016-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Autophagy, 12, 2016
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8SK5
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![BU of 8sk5 by Molmil](/molmil-images/mine/8sk5) | Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH | 著者 | Noland, C.L, Pande, K, Zhang, L, Zhou, H, Galli, J, Eddins, M, Gomez-Llorente, Y. | 登録日 | 2023-04-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants. Sci Rep, 13, 2023
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6GVF
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![BU of 6gvf by Molmil](/molmil-images/mine/6gvf) | Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine | 分子名称: | 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F. | 登録日 | 2018-06-21 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Acs Med.Chem.Lett., 10, 2019
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8CWR
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8CWT
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6CSU
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![BU of 6csu by Molmil](/molmil-images/mine/6csu) | The structure of the Cep63-Cep152 heterotetrameric complex | 分子名称: | Centrosomal protein of 152 kDa, Centrosomal protein of 63 kDa | 著者 | Lee, E, Chen, Y, Zhang, L, Kim, T.S, Ahn, J.I, Park, J.E, Lee, K.S. | 登録日 | 2018-03-21 | 公開日 | 2019-03-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat Commun, 10, 2019
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7D5Z
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![BU of 7d5z by Molmil](/molmil-images/mine/7d5z) | Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8 | 分子名称: | Envelope glycoprotein H, Envelope glycoprotein L, heavy chain of 1D8, ... | 著者 | Zhu, Q, Shan, S, Yu, J, Wang, X, Zhang, L, Zeng, M. | 登録日 | 2020-09-28 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | A Neutralizing Antibody Targeting a New Site of Vulnerability on Epstein-Barr Virus gH/gL Protects against Dual-Tropic Infection To Be Published
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6GVG
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![BU of 6gvg by Molmil](/molmil-images/mine/6gvg) | Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-4-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine | 分子名称: | 5-(6-azanyl-4-methyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F. | 登録日 | 2018-06-21 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Acs Med.Chem.Lett., 10, 2019
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6GVI
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![BU of 6gvi by Molmil](/molmil-images/mine/6gvi) | Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine | 分子名称: | 3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F. | 登録日 | 2018-06-21 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Acs Med.Chem.Lett., 10, 2019
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6GVH
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![BU of 6gvh by Molmil](/molmil-images/mine/6gvh) | Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-4-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine | 分子名称: | 5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F. | 登録日 | 2018-06-21 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Acs Med.Chem.Lett., 10, 2019
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8OZ3
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![BU of 8oz3 by Molmil](/molmil-images/mine/8oz3) | Crystal structure of scFv ATOR 1017 bound to human 4-1BB | 分子名称: | Single chain Fv, Tumor necrosis factor receptor superfamily member 9 | 著者 | Hakansson, M, Von Schantz, L, Rose, N. | 登録日 | 2023-05-08 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1. Cancer Immunol.Immunother., 72, 2023
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7VWP
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![BU of 7vwp by Molmil](/molmil-images/mine/7vwp) | Structure of the flavin-dependent monooxygenase FlsO1 from the biosynthesis of fluostatinsin | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, FlsO1, PHOSPHATE ION, ... | 著者 | Zhang, Y, Yang, C, Zhang, L, Zhang, C. | 登録日 | 2021-11-11 | 公開日 | 2022-09-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation Nat Commun, 13, 2022
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6CSV
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![BU of 6csv by Molmil](/molmil-images/mine/6csv) | The structure of the Cep63-Cep152 heterotetrameric complex | 分子名称: | Centrosomal protein of 63 kDa,Centrosomal protein of 152 kDa | 著者 | Lee, E, Chen, Y, Zhang, L, Kim, T.S, Ahn, J.I, Park, J.E, Lee, K.S. | 登録日 | 2018-03-21 | 公開日 | 2019-03-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat Commun, 10, 2019
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6IUT
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![BU of 6iut by Molmil](/molmil-images/mine/6iut) | Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AVFluIgG01 Heavy Chain, ... | 著者 | Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X. | 登録日 | 2018-11-30 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J. Biol. Chem., 294, 2019
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7OG7
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![BU of 7og7 by Molmil](/molmil-images/mine/7og7) | Crystal structure of the copper chaperone NosL from Shewanella denitrificans | 分子名称: | ACETONITRILE, COPPER (I) ION, NosL, ... | 著者 | Prasser, B, Schoener, L, Zhang, L, Einsle, O. | 登録日 | 2021-05-06 | 公開日 | 2021-07-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The Copper Chaperone NosL Forms a Heterometal Site for Cu Delivery to Nitrous Oxide Reductase. Angew.Chem.Int.Ed.Engl., 60, 2021
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5XBM
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![BU of 5xbm by Molmil](/molmil-images/mine/5xbm) | Structure of SCARB2-JL2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosome membrane protein 2, ... | 著者 | Zhang, X, Yang, P, Wang, N, Zhang, J, Li, J, Guo, H, Yin, X, Rao, Z, Wang, X, Zhang, L. | 登録日 | 2017-03-20 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.501 Å) | 主引用文献 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein Cell, 8, 2017
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8JFG
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8CTJ
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![BU of 8ctj by Molmil](/molmil-images/mine/8ctj) | Cryo-EM structure of TMEM87A | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Transmembrane protein 87A | 著者 | Hoel, C.M, Zhang, L, Brohawn, S.G. | 登録日 | 2022-05-15 | 公開日 | 2022-07-20 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (4.74 Å) | 主引用文献 | Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Elife, 11, 2022
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6KX9
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4FZO
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5LWP
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![BU of 5lwp by Molmil](/molmil-images/mine/5lwp) | Discovery of phenoxyindazoles and phenylthioindazoles as RORg inverse agonists | 分子名称: | 4-[3-[2-chloranyl-6-(trifluoromethyl)phenoxy]-5-(dimethylcarbamoyl)indazol-1-yl]benzoic acid, Nuclear receptor ROR-gamma | 著者 | Ouvry, G, Bouix-Peter, C, Ciesielski, F, Chantalat, L, Christin, O, Comino, C, Duvert, D, Feret, C, Harris, C.S, Luzy, A.-P, Musicki, B, Orfila, D, Pascau, J, Parnet, V, Perrin, A, Pierre, R, Raffin, C, Rival, Y, Taquet, N, Thoreau, E, Hennequin, L.F. | 登録日 | 2016-09-19 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of phenoxyindazoles and phenylthioindazoles as ROR gamma inverse agonists. Bioorg.Med.Chem.Lett., 26, 2016
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5IDK
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8JFN
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