Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and the peptide 3

Summary for 6S24

DescriptorPolypeptide N-acetylgalactosaminyltransferase, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (9 entities in total)
Functional Keywordsgalnac-ts, galnac-t3, long-range glycosylation preference, (glyco)peptides, molecular dynamics, specificity, enzyme kinetics, fgf23, phosphate homeostasis, transferase
Biological sourceTaeniopygia guttata (Zebra finch)
Total number of polymer chains2
Total molecular weight76035.18
Primary citation
de Las Rivas, M.,Paul Daniel, E.J.,Narimatsu, Y.,Companon, I.,Kato, K.,Hermosilla, P.,Thureau, A.,Ceballos-Laita, L.,Coelho, H.,Bernado, P.,Marcelo, F.,Hansen, L.,Maeda, R.,Lostao, A.,Corzana, F.,Clausen, H.,Gerken, T.A.,Hurtado-Guerrero, R.
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
Nat.Chem.Biol., 2020
PubMed: 31932717 (PDB entries with the same primary citation)
DOI: 10.1038/s41589-019-0444-x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2378 0.9% 5.0% 8.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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