6S24

Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and the peptide 3

Summary for 6S24

DescriptorPolypeptide N-acetylgalactosaminyltransferase, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (9 entities in total)
Functional Keywordsgalnac-ts, galnac-t3, long-range glycosylation preference, (glyco)peptides, molecular dynamics, specificity, enzyme kinetics, fgf23, phosphate homeostasis, transferase
Biological sourceTaeniopygia guttata (Zebra finch)
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Total number of polymer chains2
Total molecular weight76035.18
Authors
Primary citation
de Las Rivas, M.,Paul Daniel, E.J.,Narimatsu, Y.,Companon, I.,Kato, K.,Hermosilla, P.,Thureau, A.,Ceballos-Laita, L.,Coelho, H.,Bernado, P.,Marcelo, F.,Hansen, L.,Maeda, R.,Lostao, A.,Corzana, F.,Clausen, H.,Gerken, T.A.,Hurtado-Guerrero, R.
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
Nat.Chem.Biol., 2020
PubMed: 31932717 (PDB entries with the same primary citation)
DOI: 10.1038/s41589-019-0444-x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.12 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2378 0.9% 5.0% 8.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload