5DP7
Crystal Structure of EV71 3C Proteinase in complex with compound 5
Summary for 5DP7
Entry DOI | 10.2210/pdb5dp7/pdb |
Related | 5DP3 5DP4 5DP5 5DP6 5DP8 5DP9 5DPA |
Descriptor | 3C proteinase, ethyl (2Z,4S)-4-{[N-(3-methylbutanoyl)-L-phenylalanyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate (3 entities in total) |
Functional Keywords | hand, foot and mouth disease, 3c proteinase, peptidomimetics, drug design, rupintrivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Enterovirus A71 |
Cellular location | Host cytoplasm : A9XG43 |
Total number of polymer chains | 1 |
Total formula weight | 21849.04 |
Authors | |
Primary citation | Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta, 1860:1299-1307, 2016 Cited by PubMed: 26987809DOI: 10.1016/j.bbagen.2016.03.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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