8AYL
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![BU of 8ayl by Molmil](/molmil-images/mine/8ayl) | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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7OCA
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![BU of 7oca by Molmil](/molmil-images/mine/7oca) | Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. | 登録日 | 2021-04-26 | 公開日 | 2021-06-09 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
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7OCC
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![BU of 7occ by Molmil](/molmil-images/mine/7occ) | NTD of resting state GluA1/A2 heterotertramer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 1, ... | 著者 | Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. | 登録日 | 2021-04-26 | 公開日 | 2021-06-09 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
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7OCD
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![BU of 7ocd by Molmil](/molmil-images/mine/7ocd) | Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2, ... | 著者 | Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. | 登録日 | 2021-04-26 | 公開日 | 2021-06-09 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
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7OCE
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![BU of 7oce by Molmil](/molmil-images/mine/7oce) | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, CHOLESTEROL, ... | 著者 | Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. | 登録日 | 2021-04-26 | 公開日 | 2021-06-09 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
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7OCF
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![BU of 7ocf by Molmil](/molmil-images/mine/7ocf) | Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLOTHIAZIDE, GLUTAMIC ACID, ... | 著者 | Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. | 登録日 | 2021-04-26 | 公開日 | 2021-06-09 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
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8AYO
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![BU of 8ayo by Molmil](/molmil-images/mine/8ayo) | Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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8AYM
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![BU of 8aym by Molmil](/molmil-images/mine/8aym) | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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8AYN
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![BU of 8ayn by Molmil](/molmil-images/mine/8ayn) | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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2JY5
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![BU of 2jy5 by Molmil](/molmil-images/mine/2jy5) | |
2JY6
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![BU of 2jy6 by Molmil](/molmil-images/mine/2jy6) | |
8C2H
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![BU of 8c2h by Molmil](/molmil-images/mine/8c2h) | Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C1P
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![BU of 8c1p by Molmil](/molmil-images/mine/8c1p) | Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CYCLOTHIAZIDE, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C2I
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![BU of 8c2i by Molmil](/molmil-images/mine/8c2i) | Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C1S
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![BU of 8c1s by Molmil](/molmil-images/mine/8c1s) | Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C1R
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![BU of 8c1r by Molmil](/molmil-images/mine/8c1r) | Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C1Q
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![BU of 8c1q by Molmil](/molmil-images/mine/8c1q) | Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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7F6G
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![BU of 7f6g by Molmil](/molmil-images/mine/7f6g) | Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin receptor AT1R, CHOLESTEROL, ... | 著者 | Zhang, D, Xu, L, Zhan, Y, Guo, J, Zhang, H. | 登録日 | 2021-06-25 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists. Embo J., 42, 2023
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4U92
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![BU of 4u92 by Molmil](/molmil-images/mine/4u92) | Crystal structure of a DNA/Ba2+ G-quadruplex containing a water-mediated C-tetrad | 分子名称: | BARIUM ION, DNA (5'-D(*CP*CP*AP*KP*GP*CP*GP*TP*GP*G)-3'), MAGNESIUM ION | 著者 | Paukstelis, P.J, Zhang, D, Huang, T, Lukeman, P. | 登録日 | 2014-08-05 | 公開日 | 2014-11-26 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of a DNA/Ba2+ G-quadruplex containing a water-mediated C-tetrad. Nucleic Acids Res., 42, 2014
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6F2N
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![BU of 6f2n by Molmil](/molmil-images/mine/6f2n) | Crystal structure of BCII Metallo-beta-lactamase in complex with KDU197 | 分子名称: | (~{Z})-3-[2-(naphthalen-2-ylmethyl)phenyl]-2-sulfanyl-prop-2-enoic acid, Metallo-beta-lactamase type 2, SULFATE ION, ... | 著者 | McDonough, M.A, El-Hussein, A, Schofield, C.J, Zhang, D, Brem, J. | 登録日 | 2017-11-24 | 公開日 | 2018-10-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.149 Å) | 主引用文献 | Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases. Bioorg. Med. Chem., 26, 2018
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6EUM
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![BU of 6eum by Molmil](/molmil-images/mine/6eum) | CRYSTAL STRUCTURE OF BCII METALLO-BETA-LACTAMASE IN COMPLEX WITH DZ-307 | 分子名称: | (~{Z})-2-sulfanyl-3-[2,3,6-tris(fluoranyl)phenyl]prop-2-enoic acid, GLYCEROL, Metallo-beta-lactamase type 2, ... | 著者 | Stepanovs, D, McDonough, M.A, Schofield, C.J, Zhang, D, El-Husseiny, A, Brem, J. | 登録日 | 2017-10-30 | 公開日 | 2018-10-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases. Bioorg. Med. Chem., 26, 2018
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6EWE
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![BU of 6ewe by Molmil](/molmil-images/mine/6ewe) | Crystal structure of BCII Metallo-beta-lactamase in complex with DZ-308 | 分子名称: | (~{Z})-3-(1-benzothiophen-3-yl)-2-sulfanyl-prop-2-enoic acid, GLYCEROL, Metallo-beta-lactamase type 2, ... | 著者 | Stepanovs, D, McDonough, M.A, Schofield, C.J, Zhang, D, El-Husseiny, A, Brem, J. | 登録日 | 2017-11-03 | 公開日 | 2018-10-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases. Bioorg. Med. Chem., 26, 2018
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5JMX
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![BU of 5jmx by Molmil](/molmil-images/mine/5jmx) | Crystal Structure of BcII metallo-beta-lactamase in complex with DZ-305 | 分子名称: | (2Z)-3-(4-fluorophenyl)-2-sulfanylprop-2-enoic acid, GLYCEROL, Metallo-beta-lactamase type 2, ... | 著者 | Stepanovs, D, McDonough, M.A, Schofield, C.J, Zhang, D, Brem, J. | 登録日 | 2016-04-29 | 公開日 | 2017-05-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases. Bioorg. Med. Chem., 26, 2018
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3NS8
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![BU of 3ns8 by Molmil](/molmil-images/mine/3ns8) | |
8P3X
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![BU of 8p3x by Molmil](/molmil-images/mine/8p3x) | Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 1 | 分子名称: | Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | 著者 | Krieger, J.M, Zhang, D, Yamashita, K, Greger, I.H. | 登録日 | 2023-05-18 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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