7DOR
 
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7DPR
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7DPS
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7DQH
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7DQI
 | | E. coli GyrB ATPase domain in complex with Esculetin | | 分子名称: | 1H-benzimidazol-2-amine, 6,7-bis(oxidanyl)chromen-2-one, DNA gyrase subunit B, ... | | 著者 | Yu, Y, Zhou, H. | | 登録日 | 2020-12-23 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Identification of new building blocks by fragment screening for discovering GyrB inhibitors.
Bioorg.Chem., 114, 2021
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7DQJ
 | | E. coli GyrB ATPase domain in complex with 3,4-Dihydroxyacetophenone | | 分子名称: | 1-[3,4-bis(oxidanyl)phenyl]ethanone, 1H-benzimidazol-2-amine, DNA gyrase subunit B, ... | | 著者 | Yu, Y, Zhou, H. | | 登録日 | 2020-12-24 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Identification of new building blocks by fragment screening for discovering GyrB inhibitors.
Bioorg.Chem., 114, 2021
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7DQF
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7DQU
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7DQL
 | | E. coli GyrB ATPase domain in complex with 4-chlorobenzene-1,2-diol | | 分子名称: | 1H-benzimidazol-2-amine, 4-CHLOROBENZENE-1,2-DIOL, DNA gyrase subunit B, ... | | 著者 | Yu, Y, Zhou, H. | | 登録日 | 2020-12-24 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Identification of new building blocks by fragment screening for discovering GyrB inhibitors.
Bioorg.Chem., 114, 2021
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7DQM
 | | E. coli GyrB ATPase domain in complex with Naringenin | | 分子名称: | 1H-benzimidazol-2-amine, DNA gyrase subunit B, PHOSPHATE ION, ... | | 著者 | Yu, Y, Zhou, H. | | 登録日 | 2020-12-24 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Identification of new building blocks by fragment screening for discovering GyrB inhibitors.
Bioorg.Chem., 114, 2021
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7DQS
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7DQW
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4MKI
 | | Cobalt transporter ATP-binding subunit | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Energy-coupling factor transporter ATP-binding protein EcfA2, SULFATE ION | | 著者 | Yu, Y, Zhang, L, Chai, C.L, Heymann, D. | | 登録日 | 2013-09-05 | | 公開日 | 2013-10-30 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for a homodimeric ATPase subunit of an ECF transporter
Protein Cell, 4, 2013
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5JWA
 | | the structure of malaria PfNDH2 | | 分子名称: | ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, FRAGMENT OF TRITON X-100, ... | | 著者 | Yu, Y, Yang, Y.Q, Li, X.L, Yu, J, Ge, J.P, Li, J, Rao, Y, Yang, M.J. | | 登録日 | 2016-05-11 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.162 Å) | | 主引用文献 | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
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5JWC
 | | Structure of NDH2 from plasmodium falciparum in complex with RYL-552 | | 分子名称: | 5-fluoro-3-methyl-2-{4-[4-(trifluoromethoxy)benzyl]phenyl}quinolin-4(1H)-one, FLAVIN-ADENINE DINUCLEOTIDE, FRAGMENT OF TRITON X-100, ... | | 著者 | Yu, Y. | | 登録日 | 2016-05-12 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.051 Å) | | 主引用文献 | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
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5JWB
 | | Structure of NDH2 from plasmodium falciparum in complex with NADH | | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Yu, Y, Li, X.L. | | 登録日 | 2016-05-12 | | 公開日 | 2017-03-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
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7XRJ
 | | crystal structure of N-acetyltransferase DgcN-25328 | | 分子名称: | Putative NAD-dependent epimerase/dehydratase family protein, SULFATE ION | | 著者 | Zhang, Y.Z, Yu, Y, Cao, H.Y, Chen, X.L, Wang, P. | | 登録日 | 2022-05-10 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Novel D-glutamate catabolic pathway in marine Proteobacteria and halophilic archaea.
Isme J, 17, 2023
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8T8E
 | | cryoEM structure of Smc5/6 5mer | | 分子名称: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 5, Structural maintenance of chromosomes protein 6 | | 著者 | Yu, Y, Patel, D.J. | | 登録日 | 2023-06-22 | | 公開日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8T8F
 | | Smc5/6 8mer | | 分子名称: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 4, Non-structural maintenance of chromosome element 5, ... | | 著者 | Yu, Y, Patel, D.J. | | 登録日 | 2023-06-22 | | 公開日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8T66
 | | cA6 bound Cam1 | | 分子名称: | Cam1, RNA (5'-R(P*AP*AP*AP*AP*A)-3') | | 著者 | Yu, Y, Patel, D.J. | | 登録日 | 2023-06-15 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The CRISPR effector Cam1 mediates membrane depolarization for phage defence.
Nature, 625, 2024
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8T64
 | | Apo Cam1(42-206) | | 分子名称: | Cam1 | | 著者 | Yu, Y, Patel, D.J. | | 登録日 | 2023-06-15 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The CRISPR effector Cam1 mediates membrane depolarization for phage defence.
Nature, 625, 2024
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8T65
 | | cA4 bound Cam1 | | 分子名称: | Cam1, RNA (5'-R(P*AP*AP*AP*A)-3') | | 著者 | Yu, Y, Patel, D.J. | | 登録日 | 2023-06-15 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | The CRISPR effector Cam1 mediates membrane depolarization for phage defence.
Nature, 625, 2024
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8RXR
 | | Crystal structure of VPS34 in complex with inhibitor SB02024 | | 分子名称: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | | 登録日 | 2024-02-07 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Mol Oncol, 18, 2024
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2BB0
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5XHS
 | | Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA | | 分子名称: | (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, 7-AMINO-4-METHYL-CHROMEN-2-ONE, NAD-dependent protein deacylase sirtuin-5, ... | | 著者 | Yu, Y, Li, B, Chen, Q. | | 登録日 | 2017-04-24 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design
Rsc Adv, 7, 2017
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