4GYY
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![BU of 4gyy by Molmil](/molmil-images/mine/4gyy) | Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc and a peptide substrate | 分子名称: | (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, Casein kinase II subunit alpha, SULFATE ION, ... | 著者 | Lazarus, M.B, Jiang, J, Gloster, T.M, Zandberg, W.F, Vocadlo, D.J, Walker, S. | 登録日 | 2012-09-05 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat.Chem.Biol., 8, 2012
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4GZ6
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![BU of 4gz6 by Molmil](/molmil-images/mine/4gz6) | Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc | 分子名称: | (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, SULFATE ION, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | 著者 | Lazarus, M.B, Jiang, J, Gloster, T.M, Zandberg, W.F, Vocadlo, D.J, Walker, S. | 登録日 | 2012-09-06 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat.Chem.Biol., 8, 2012
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4N39
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4N3B
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![BU of 4n3b by Molmil](/molmil-images/mine/4n3b) | Crystal Structure of human O-GlcNAc Transferase bound to a peptide from HCF-1 pro-repeat2(1-26)E10Q and UDP-5SGlcNAc | 分子名称: | (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, Host cell factor 1, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | 著者 | Lazarus, M.B, Herr, W, Walker, S. | 登録日 | 2013-10-06 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science, 342, 2013
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1KP7
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![BU of 1kp7 by Molmil](/molmil-images/mine/1kp7) | Conserved RNA Structure within the HCV IRES eIF3 Binding Site | 分子名称: | Hepatitis C Virus Internal Ribosome Entry Site Fragment | 著者 | Gallego, J, Klinck, R, Collier, A.J, Cole, P.T, Harris, S.J, Harrison, G.P, Aboul-ela, F, Walker, S, Varani, G. | 登録日 | 2001-12-29 | 公開日 | 2002-04-10 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A conserved RNA structure within the HCV IRES eIF3-binding site. Nat.Struct.Biol., 9, 2002
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4N3A
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4N3C
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1FQZ
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![BU of 1fqz by Molmil](/molmil-images/mine/1fqz) | NMR VALIDATED MODEL OF DOMAIN IIID OF HEPATITIS C VIRUS INTERNAL RIBOSOME ENTRY SITE | 分子名称: | HEPATITIS C VIRUS IRES DOMAIN IIID | 著者 | Klinck, R, Westhof, E, Walker, S, Afshar, M, Collier, A, Aboul-ela, F. | 登録日 | 2000-09-07 | 公開日 | 2001-01-17 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A potential RNA drug target in the hepatitis C virus internal ribosomal entry site. RNA, 6, 2000
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5HGV
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![BU of 5hgv by Molmil](/molmil-images/mine/5hgv) | Structure of an O-GlcNAc transferase point mutant, D554N in complex with peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, TYR-PRO-GLY-GLY-SER-THR-PRO-VAL-SER-SER-ALA-ASN-MET-MET, ... | 著者 | Janetzko, J, Lazarus, M.B, Walker, S. | 登録日 | 2016-01-08 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | How the glycosyltransferase OGT catalyzes amide bond cleavage. Nat.Chem.Biol., 12, 2016
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4P32
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![BU of 4p32 by Molmil](/molmil-images/mine/4p32) | Crystal structure of E. coli LptB in complex with ADP-magnesium | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lipopolysaccharide export system ATP-binding protein LptB, MAGNESIUM ION | 著者 | Sherman, D.J, Lazarus, M.B, Murphy, L, Liu, C, Walker, S, Ruiz, N, Kahne, D. | 登録日 | 2014-03-05 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proc.Natl.Acad.Sci.USA, 111, 2014
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4P33
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![BU of 4p33 by Molmil](/molmil-images/mine/4p33) | Crystal structure of E. coli LptB-E163Q in complex with ATP-sodium | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Lipopolysaccharide export system ATP-binding protein LptB, ... | 著者 | Sherman, D.J, Lazarus, M.B, Murphy, L, Liu, C, Walker, S, Ruiz, N, Kahne, D. | 登録日 | 2014-03-05 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proc.Natl.Acad.Sci.USA, 111, 2014
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4P31
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![BU of 4p31 by Molmil](/molmil-images/mine/4p31) | Crystal structure of a selenomethionine derivative of E. coli LptB in complex with ADP-Magensium | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lipopolysaccharide export system ATP-binding protein LptB, MAGNESIUM ION | 著者 | Sherman, D.J, Lazarus, M.B, Murphy, L, Liu, C, Walker, S, Ruiz, N, Kahne, D. | 登録日 | 2014-03-05 | 公開日 | 2014-03-26 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proc.Natl.Acad.Sci.USA, 111, 2014
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2OQO
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4WZJ
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![BU of 4wzj by Molmil](/molmil-images/mine/4wzj) | Spliceosomal U4 snRNP core domain | 分子名称: | Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ... | 著者 | Leung, A.K.W, Nagai, K, Li, J. | 登録日 | 2014-11-19 | 公開日 | 2015-01-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. Nature, 473, 2011
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3CW1
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![BU of 3cw1 by Molmil](/molmil-images/mine/3cw1) | Crystal Structure of Human Spliceosomal U1 snRNP | 分子名称: | Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ... | 著者 | Pomeranz Krummel, D.A, Oubridge, C, Leung, A.K, Li, J, Nagai, K. | 登録日 | 2008-04-21 | 公開日 | 2009-03-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (5.493 Å) | 主引用文献 | Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution. Nature, 458, 2009
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8DD5
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![BU of 8dd5 by Molmil](/molmil-images/mine/8dd5) | Crystal structure of KAT6A in complex with inhibitor CTx-648 (PF-9363) | 分子名称: | 2,6-dimethoxy-N-{4-methoxy-6-[(1H-pyrazol-1-yl)methyl]-1,2-benzoxazol-3-yl}benzene-1-sulfonamide, Histone acetyltransferase KAT6A, ZINC ION | 著者 | Greasley, S.E, Johnson, E, Brodsky, O. | 登録日 | 2022-06-17 | 公開日 | 2023-07-05 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Targeting KAT6A/KAT6B dependencies in breast cancer with a novel selective, orally bioavailable KAT6 inhibitor, CTx-648/PF-9363 To Be Published
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7AUD
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7AUC
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6PL5
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![BU of 6pl5 by Molmil](/molmil-images/mine/6pl5) | Structural coordination of polymerization and crosslinking by a peptidoglycan synthase complex | 分子名称: | Penicillin-binding protein 2/cell division protein FtsI, Peptidoglycan glycosyltransferase RodA, Unknown peptide | 著者 | Sjodt, M, Rohs, P.D.A, Erlandson, S.C, Zheng, S, Rudner, D.Z, Bernhardt, T.G, Kruse, A.C. | 登録日 | 2019-06-30 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol, 5, 2020
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6PL6
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![BU of 6pl6 by Molmil](/molmil-images/mine/6pl6) | Structural coordination of polymerization and crosslinking by a peptidoglycan synthase complex | 分子名称: | (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Penicillin-binding protein 2/cell division protein FtsI, Peptidoglycan glycosyltransferase RodA, ... | 著者 | Sjodt, M, Rohs, P.D.A, Erlandson, S.C, Zheng, S, Rudner, D.Z, Bernhardt, T.G, Kruse, A.C. | 登録日 | 2019-06-30 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol, 5, 2020
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6BAR
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![BU of 6bar by Molmil](/molmil-images/mine/6bar) | Crystal structure of Thermus thermophilus Rod shape determining protein RodA (Q5SIX3_THET8) | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Rod shape determining protein RodA | 著者 | Sjodt, M, Brock, K, Dobihal, G, Rohs, P.D.A, Green, A.G, Hopf, T.A, Meeske, A.J, Marks, D.S, Bernhardt, T.G, Rudner, D.Z, Kruse, A.C. | 登録日 | 2017-10-15 | 公開日 | 2018-03-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.908 Å) | 主引用文献 | Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. Nature, 556, 2018
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6BAS
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![BU of 6bas by Molmil](/molmil-images/mine/6bas) | Crystal structure of Thermus thermophilus Rod shape determining protein RodA D255A mutant (Q5SIX3_THET8) | 分子名称: | CHLORIDE ION, Peptidoglycan glycosyltransferase RodA | 著者 | Sjodt, M, Brock, K, Dobihal, G, Rohs, P.D.A, Green, A.G, Hopf, T.A, Meeske, A.J, Marks, D.S, Bernhardt, T.G, Rudner, D.Z, Kruse, A.C. | 登録日 | 2017-10-15 | 公開日 | 2018-03-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.194 Å) | 主引用文献 | Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. Nature, 556, 2018
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5J3S
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![BU of 5j3s by Molmil](/molmil-images/mine/5j3s) | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor | 分子名称: | 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, Tyrosyl-DNA phosphodiesterase 2 | 著者 | Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. | 登録日 | 2016-03-31 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
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5J3Z
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![BU of 5j3z by Molmil](/molmil-images/mine/5j3z) | Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, ACETATE ION, ... | 著者 | Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. | 登録日 | 2016-03-31 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
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5J42
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![BU of 5j42 by Molmil](/molmil-images/mine/5j42) | Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, 10-(4-hydroxyphenyl)-2,4-dioxo-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, GLYCEROL, ... | 著者 | Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. | 登録日 | 2016-03-31 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
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