5J3Z
Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor
Summary for 5J3Z
Entry DOI | 10.2210/pdb5j3z/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 2, 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | tyrosyl dna phosphodiesterase 2 catalytic domain, hydrolase |
Biological source | Mus musculus (House Mouse) |
Cellular location | Nucleus : Q9JJX7 |
Total number of polymer chains | 2 |
Total formula weight | 60019.27 |
Authors | Hornyak, P.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W. (deposition date: 2016-03-31, release date: 2016-05-04, Last modification date: 2024-01-10) |
Primary citation | Hornyak, P.,Askwith, T.,Walker, S.,Komulainen, E.,Paradowski, M.,Pennicott, L.E.,Bartlett, E.J.,Brissett, N.C.,Raoof, A.,Watson, M.,Jordan, A.M.,Ogilvie, D.J.,Ward, S.E.,Atack, J.R.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W. Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473:1869-1879, 2016 Cited by PubMed: 27099339DOI: 10.1042/BCJ20160180 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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