3N6N
 
 | | crystal structure of EV71 RdRp in complex with Br-UTP | | 分子名称: | 5-bromouridine 5'-(tetrahydrogen triphosphate), NICKEL (II) ION, RNA-dependent RNA polymerase | | 著者 | Wu, Y, Lou, Z.Y, Miao, Y, Yu, Y, Rao, Z.H. | | 登録日 | 2010-05-26 | | 公開日 | 2011-06-15 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
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6JDY
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6ABR
 | | Actin interacting protein 5 (Aip5, wild type) | | 分子名称: | Actin binding protein | | 著者 | Sun, J, Xie, Y, Toh, J.D.W, Hong, W, MIao, Y, Gao, Y.G. | | 登録日 | 2018-07-23 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.
Nat Commun, 10, 2019
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6ABS
 | | Actin interacting protein 5 (Aip5, mutant) | | 分子名称: | Actin binding protein, PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL | | 著者 | Sun, J, Ying, X, Toh, J, Hong, W, Miao, Y, Gao, Y.G. | | 登録日 | 2018-07-23 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.
Nat Commun, 10, 2019
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6M4C
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6JDT
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6JE2
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6JE0
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6JDZ
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6JE1
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8BX6
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8BXH
 | | Crystal structure of JAK2 JH1 in complex with momelotinib | | 分子名称: | MALONATE ION, Momelotinib, Tyrosine-protein kinase JAK2 | | 著者 | Haikarainen, T. | | 登録日 | 2022-12-08 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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8BXC
 | | Crystal structure of JAK2 JH1 in complex with itacitinib | | 分子名称: | Itacitinib, MALONATE ION, Tyrosine-protein kinase JAK2 | | 著者 | Haikarainen, T. | | 登録日 | 2022-12-08 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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8BX9
 | | Crystal structure of JAK2 JH1 in complex with ilginatinib | | 分子名称: | DIMETHYL SULFOXIDE, Ilginatinib, Tyrosine-protein kinase JAK2 | | 著者 | Haikarainen, T. | | 登録日 | 2022-12-08 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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7CCG
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6PZQ
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6IQI
 | | crystal structure of Arabidopsis thaliana Profilin 2 | | 分子名称: | Profilin-2 | | 著者 | Qiao, Z, Gao, Y. | | 登録日 | 2018-11-08 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and computational examination of theArabidopsisprofilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly.
J.Biol.Chem., 294, 2019
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3N6L
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6IQJ
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6IQK
 | | crystal structure of Arabidopsis thaliana Profilin 3 | | 分子名称: | AtPRF3, Profilin-5 | | 著者 | Qiao, Z, Gao, Y. | | 登録日 | 2018-11-08 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural and computational examination of theArabidopsisprofilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly.
J.Biol.Chem., 294, 2019
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6IQF
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3TKY
 | | Monolignol o-methyltransferase (momt) | | 分子名称: | (Iso)eugenol O-methyltransferase, 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenol, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Bhuiya, M.W, Liu, C.J. | | 登録日 | 2011-08-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | An engineered monolignol 4-o-methyltransferase depresses lignin biosynthesis and confers novel metabolic capability in Arabidopsis.
Plant Cell, 24, 2012
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6WW2
 | | Structure of human Frizzled5 by fiducial-assisted cryo-EM | | 分子名称: | Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | | 著者 | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | | 登録日 | 2020-05-07 | | 公開日 | 2020-08-19 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Elife, 9, 2020
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8DCS
 | | Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | | 分子名称: | 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | | 登録日 | 2022-06-17 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies.
Nat Commun, 13, 2022
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8DCR
 | | Cryo-EM structure of dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | | 分子名称: | DOBUTAMINE, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | | 登録日 | 2022-06-17 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies.
Nat Commun, 13, 2022
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