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6Y1Q
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BU of 6y1q by Molmil
Cortistatin analog with improved immunoregulatory activity
分子名称: Analog 5, OCTANOIC ACID (CAPRYLIC ACID)
著者Rol, A.
登録日2020-02-13
公開日2021-01-27
最終更新日2024-07-10
実験手法SOLUTION NMR
主引用文献Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease.
Nat Commun, 12, 2021
6ZMN
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BU of 6zmn by Molmil
Crystal structure of the Smad3-Smad5 MH1 domain chimera bound to the GGCGC site
分子名称: 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), ...
著者Pluta, R, Macias, M.J.
登録日2020-07-03
公開日2020-08-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.333 Å)
主引用文献Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes.
Comput Struct Biotechnol J, 19, 2021
7PVU
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BU of 7pvu by Molmil
Crystal structure of p38alpha C162S in complex with CAS2094511-69-8, P 1 21 1
分子名称: Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)-2-fluorobenzene-1-sulfonamide
著者Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R.
登録日2021-10-05
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.154 Å)
主引用文献Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway.
Nat Commun, 14, 2023
6TBZ
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BU of 6tbz by Molmil
Crystal structure of the MH1 domain of Smad5-Smad3 chimera construct bound to the GGCGC site
分子名称: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 5, ZINC ION
著者Pluta, R, Macias, M.J.
登録日2019-11-04
公開日2019-11-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.782 Å)
主引用文献Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes.
Comput Struct Biotechnol J, 19, 2021
6TCE
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BU of 6tce by Molmil
Crystal structure of the GGCT site-bound MH1 domain of Smad5 containing a GGGS insertion in the Loop1
分子名称: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 5, ZINC ION
著者Pluta, R, Macias, M.J.
登録日2019-11-05
公開日2019-11-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes.
Comput Struct Biotechnol J, 19, 2021
6FQP
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BU of 6fqp by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 with its consensus DNA
分子名称: CALCIUM ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
著者Guca, E, Macias, M.J.
登録日2018-02-14
公開日2018-07-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
6FQQ
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BU of 6fqq by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
分子名称: CHLORIDE ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
著者Guca, E, Macias, M.J.
登録日2018-02-14
公開日2018-07-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.25000262 Å)
主引用文献TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
6FZS
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BU of 6fzs by Molmil
Crystal structure of Smad5-MH1 bound to the GGCGC site.
分子名称: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 5, ZINC ION
著者Kaczmarska, Z, Marquez, J.A, Macias, M.J.
登録日2018-03-15
公開日2019-10-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
Computational and Structural Biotechnology Journal, 19, 2021
6FZT
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BU of 6fzt by Molmil
Crystal structure of Smad8_9-MH1 bound to the GGCGC site.
分子名称: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), GLYCEROL, Mothers against decapentaplegic homolog 9, ...
著者Kaczmarska, Z, Marquez, J.A, Macias, M.J.
登録日2018-03-15
公開日2019-10-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
Computational and Structural Biotechnology Journal, 19, 2021
7YZE
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BU of 7yze by Molmil
Crystal structure of the human FoxA2 bound to the TGTTTACT site (forkhead motif GTAAACA)
分子名称: DNA (5'-D(*AP*GP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*GP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*CP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*CP*T)-3'), Hepatocyte nuclear factor 3-beta, ...
著者Pluta, R, Macias, M.J.
登録日2022-02-19
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
7YZF
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BU of 7yzf by Molmil
Crystal structure of the human FoxA2 bound to the TGTTTATT site (forkhead motif ATAAACA)
分子名称: DNA (5'-D(P*AP*GP*AP*TP*TP*GP*TP*TP*TP*AP*TP*TP*GP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*AP*TP*AP*AP*AP*CP*AP*AP*TP*CP*T)-3'), Hepatocyte nuclear factor 3-beta, ...
著者Pluta, R, Macias, M.J.
登録日2022-02-19
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
7Z6I
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BU of 7z6i by Molmil
Crystal structure of p38alpha C162S in complex with SB20358 and CAS 2094667-81-7 (behind catalytic site; Y35 in), P 21 21 21
分子名称: 4-[4-(4-fluorophenyl)-2-[4-[methyl(oxidanyl)-$l^{3}-sulfanyl]phenyl]-1~{H}-imidazol-5-yl]pyridine, Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)benzenesulfonamide
著者Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R.
登録日2022-03-11
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway.
Nat Commun, 14, 2023
7Z9T
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BU of 7z9t by Molmil
Crystal structure of p38alpha C162S in complex with ATPgS and CAS 2094667-81-7 (in catalytic site, Y35 out), P 1 21 1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)benzenesulfonamide
著者Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R.
登録日2022-03-21
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway.
Nat Commun, 14, 2023
7YZA
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BU of 7yza by Molmil
Crystal structure of the zebrafish FoxH1 bound to the TGTGTATT site
分子名称: DNA (5'-D(*AP*GP*AP*TP*TP*GP*TP*GP*TP*AP*TP*TP*GP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*CP*AP*AP*TP*AP*CP*AP*CP*AP*AP*TP*CP*T)-3'), Forkhead box protein H1, ...
著者Pluta, R, Macias, M.J.
登録日2022-02-19
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
7YZC
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BU of 7yzc by Molmil
Crystal structure of the zebrafish FoxH1 bound to the TGTTTATT site
分子名称: ACETATE ION, DNA (5'-D(*AP*GP*AP*TP*TP*GP*TP*TP*TP*AP*TP*TP*GP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*CP*AP*AP*TP*AP*AP*AP*CP*AP*AP*TP*CP*T)-3'), ...
著者Pluta, R, Macias, M.J.
登録日2022-02-19
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
7YZ7
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BU of 7yz7 by Molmil
Crystal structure of the zebrafish FoxH1 bound to the TGTGGATT site
分子名称: DNA (5'-D(*AP*GP*AP*TP*TP*GP*TP*GP*GP*AP*TP*TP*GP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*CP*AP*AP*TP*CP*CP*AP*CP*AP*AP*TP*CP*T)-3'), Forkhead box protein H1, ...
著者Pluta, R, Macias, M.J.
登録日2022-02-18
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
7YZB
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BU of 7yzb by Molmil
Crystal structure of the human FoxH1 bound to the TGTGGATT site
分子名称: DNA (5'-D(*AP*GP*AP*TP*TP*GP*TP*GP*GP*AP*TP*TP*GP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*CP*AP*AP*TP*CP*CP*AP*CP*AP*AP*TP*CP*T)-3'), Forkhead box protein H1, ...
著者Pluta, R, Macias, M.J.
登録日2022-02-19
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
7YZD
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BU of 7yzd by Molmil
Crystal structure of the zebrafish FoxH1 bound to the TGTTTACT site (fkh motif GTAAACA)
分子名称: ACETATE ION, DNA (5'-D(*TP*CP*TP*CP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*CP*T)-3'), DNA (5'-D(P*AP*GP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*GP*AP*GP*A)-3'), ...
著者Pluta, R, Macias, M.J.
登録日2022-02-19
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
7YZG
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BU of 7yzg by Molmil
Crystal structure of the Xenopus FoxH1 bound to the TGTGGATT site
分子名称: DNA (5'-D(*CP*AP*GP*AP*TP*TP*GP*TP*GP*GP*AP*TP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*TP*CP*AP*AP*TP*CP*CP*AP*CP*AP*AP*TP*CP*TP*G)-3'), Forkhead box protein H1
著者Pluta, R, Macias, M.J.
登録日2022-02-19
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022
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