7D9S
| Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | 著者 | Chen, L, Liu, R, Kang, Y. | 登録日 | 2020-10-14 | 公開日 | 2021-08-11 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9T
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7ARO
| Crystal structure of the non-ribose partial agonist LUF5833 bound to the adenosine A2A receptor | 分子名称: | 2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | 著者 | Verdon, G, Amelia, T, van Veldhoven, J, Falsini, M, Liu, R, Heitman, L, van Westen, G, Segala, E, Cheng, R, Cooke, R, van der Es, D, Ijzerman, A. | 登録日 | 2020-10-25 | 公開日 | 2021-04-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.119 Å) | 主引用文献 | Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A 2A Receptor. J.Med.Chem., 64, 2021
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8XN7
| Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f | 分子名称: | 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 | 著者 | Huang, W.X, Liu, R, Ding, K. | 登録日 | 2023-12-29 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur.J.Med.Chem., 269, 2024
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6JYV
| Structure of an isopenicillin N synthase from Pseudomonas aeruginosa PAO1 | 分子名称: | Probable iron/ascorbate oxidoreductase, SODIUM ION | 著者 | Hao, Z, Che, S, Wang, R, Liu, R, Zhang, Q, Bartlam, M. | 登録日 | 2019-04-28 | 公開日 | 2019-05-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | Structural characterization of an isopenicillin N synthase family oxygenase from Pseudomonas aeruginosa PAO1. Biochem.Biophys.Res.Commun., 514, 2019
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6JT2
| Structure of human soluble guanylate cyclase in the NO activated state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | 登録日 | 2019-04-08 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT0
| Structure of human soluble guanylate cyclase in the unliganded state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | 登録日 | 2019-04-08 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT1
| Structure of human soluble guanylate cyclase in the heme oxidised state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | 登録日 | 2019-04-08 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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8IM0
| mCherry-LaM8 complex | 分子名称: | LaM8, MCherry fluorescent protein | 著者 | Liang, H, Liu, R, Ding, Y. | 登録日 | 2023-03-05 | 公開日 | 2023-06-21 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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8ILX
| mCherry-LaM3 complex | 分子名称: | LAM3, MCherry fluorescent protein | 著者 | Liang, H, Liu, R, Ding, Y. | 登録日 | 2023-03-05 | 公開日 | 2023-06-21 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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8IM1
| mCherry-LaM1 complex | 分子名称: | LaM1, MCherry fluorescent protein, SULFATE ION | 著者 | Liang, H, Liu, R, Ding, Y. | 登録日 | 2023-03-05 | 公開日 | 2023-06-21 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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2F9V
| HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines | 分子名称: | (2S,8R,9S,15S)-15-CYCLOHEXYL-9,12-BIS(CYCLOPROPYLMETHYL)-8-HYDROXY-20-METHYL-4,7,11,14,17-PENTAOXO-2-PHENYL-18-OXA-3,6,10,12,13,16-HEXAAZAHENICOSAN-1-OIC ACID, NS3 protease/helicase, ZINC ION, ... | 著者 | Bogen, S.L, Ruan, S, Liu, R, Agrawal, S, Pichardo, J, Prongay, A, Baroudy, B, Saksena, A, Girijavallabhan, V, Njoroge, F.G. | 登録日 | 2005-12-06 | 公開日 | 2007-01-09 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Depeptidization efforts on P3-P2 a-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity. Bioorg.Med.Chem.Lett., 16, 2006
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4WOY
| Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1 | 分子名称: | Mitochondrial dynamics protein MID49 | 著者 | Loson, O.C, Meng, S, Ngo, H.B, Liu, R, Kaiser, J.T, Chan, D.C. | 登録日 | 2014-10-17 | 公開日 | 2015-01-28 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1. Protein Sci., 24, 2015
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4DE6
| Horse spleen apo-ferritin complex with arachidonic acid | 分子名称: | ARACHIDONIC ACID, CADMIUM ION, Ferritin light chain, ... | 著者 | Bu, W, Liu, R, Dmochowski, I.J, Loll, P.J, Eckenhoff, R.G. | 登録日 | 2012-01-19 | 公開日 | 2012-03-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Ferritin couples iron and fatty acid metabolism. Faseb J., 26, 2012
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7VSI
| Structure of human SGLT2-MAP17 complex bound with empagliflozin | 分子名称: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, PALMITIC ACID, PDZK1-interacting protein 1, ... | 著者 | Chen, L, Niu, Y, Liu, R. | 登録日 | 2021-10-26 | 公開日 | 2021-12-15 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. Nature, 601, 2022
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7VSP
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2R13
| Crystal structure of human mitoNEET reveals a novel [2Fe-2S] cluster coordination | 分子名称: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, Zinc finger CDGSH domain-containing protein 1 | 著者 | Hou, X, Liu, R, Ross, S, Smart, E.J, Zhu, H, Gong, W. | 登録日 | 2007-08-22 | 公開日 | 2007-09-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystallographic studies of human MitoNEET J.Biol.Chem., 282, 2007
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3RD0
| Horse spleen apo-ferritin with bound thiopental | 分子名称: | 5-ethyl-5-[(2R)-pentan-2-yl]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione, CADMIUM ION, Ferritin light chain, ... | 著者 | Oakley, S.H, Vedula, L.S, Xi, J, Liu, R, Eckenhoff, R.G, Loll, P.J. | 登録日 | 2011-03-31 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | High resolution view of barbiturate recognition by a protein binding site to be published
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3RAV
| Horse spleen apo-ferritin with bound Pentobarbital | 分子名称: | 5-ethyl-5-[(2S)-pentan-2-yl]pyrimidine-2,4,6(1H,3H,5H)-trione, CADMIUM ION, Ferritin light chain, ... | 著者 | Oakley, S.H, Vedula, L.S, Xi, J, Liu, R, Eckenhoff, R.G, Loll, P.J. | 登録日 | 2011-03-28 | 公開日 | 2011-05-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | High resolution view of barbiturate recognition by a protein binding site to be published
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2LSP
| solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide | 分子名称: | Bromodomain-containing protein 4, NF-kB-K310ac peptide | 著者 | Zhang, G, Liu, R, Zhong, Y, Plotnikov, A.N, Zhang, W, Rusinova, E, Gerona-Nevarro, G, Moshkina, N, Joshua, J, Chuang, P.Y, Ohlmeyer, M, He, J, Zhou, M.-M. | 登録日 | 2012-05-03 | 公開日 | 2012-07-18 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J.Biol.Chem., 287, 2012
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7XQV
| The complex of nanobody Rh57 binding to GTP-bound RhoA active form | 分子名称: | ALANINE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Zhang, Y.R, Liu, R, Ding, Y. | 登録日 | 2022-05-09 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structural insights into the binding of nanobody Rh57 to active RhoA-GTP. Biochem.Biophys.Res.Commun., 616, 2022
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1PFN
| PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 16-27 OF A 27-MODEL SET. | 分子名称: | PF4-M2 CHIMERA | 著者 | Mayo, K.H, Roongta, V, Ilyina, E, Milius, R, Barker, S, Quinlan, C, La Rosa, G, Daly, T.J. | 登録日 | 1995-07-18 | 公開日 | 1996-01-29 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. Biochemistry, 34, 1995
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1PFM
| PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 1-15 OF A 27-MODEL SET. | 分子名称: | PF4-M2 CHIMERA | 著者 | Mayo, K.H, Roongta, V, Ilyina, E, Milius, R, Barker, S, Quinlan, C, La Rosa, G, Daly, T.J. | 登録日 | 1995-07-18 | 公開日 | 1996-01-29 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. Biochemistry, 34, 1995
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8YGH
| pP1192R-apo open state | 分子名称: | DNA topoisomerase 2 | 著者 | Sun, J.Q, Liu, R.L. | 登録日 | 2024-02-26 | 公開日 | 2024-09-18 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural basis for difunctional mechanism of m-AMSA against African swine fever virus pP1192R. Nucleic Acids Res., 2024
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8YGE
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