7W1C
 
 | | Crystal structure of Klebsiella pneumoniae K1 capsule-specific polysaccharide lyase in a P1 crystal form | | 分子名称: | (2S)-2-hydroxybutanedioic acid, GLYCEROL, IMIDAZOLE, ... | | 著者 | Tu, I.F, Huang, K.F, Wu, S.H. | | 登録日 | 2021-11-19 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use.
J.Biomed.Sci., 29, 2022
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8EI8
 | | Crystal structure of the WWP2 HECT domain in complex with H308, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, H308, N,N'-(1,4-phenylene)diacetamide, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI1
 | | Crystal structure of the N-terminal domain of CUL4B in complex with H316, a Helicon Polypeptide | | 分子名称: | Cullin-4B, H316, N,N'-(1,4-phenylene)diacetamide | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI7
 | | Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI2
 | | Crystal structure of the N-terminal domain of CUL5 in complex with H314, a Helicon Polypeptide | | 分子名称: | Cullin-5, H314, N,N'-(1,4-phenylene)diacetamide | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EHZ
 | | Crystal structure of the STUB1 TPR domain in complex with H317, a Helicon Polypeptide | | 分子名称: | E3 ubiquitin-protein ligase CHIP, H317, N,N'-(1,4-phenylene)diacetamide | | 著者 | Li, K, Swiecicki, J.-M, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI0
 | | Crystal structure of the STUB1 TPR domain in complex with H318, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CHIP, H318, ... | | 著者 | Li, K, Swiecicki, J.-M, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI3
 | | Crystal structure of VHL in complex with H313, a Helicon Polypeptide | | 分子名称: | Elongin-B, Elongin-C, H313, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI6
 | | Crystal structure of the WWP2 HECT domain in complex with H305, a Helicon Polypeptide | | 分子名称: | H305, N,N'-(1,4-phenylene)diacetamide, NEDD4-like E3 ubiquitin-protein ligase WWP2 | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.62 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI5
 | | Crystal structure of the WWP2 HECT domain in complex with H301, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, H301, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI4
 | | Crystal structure of the WWP1 HECT domain in complex with H302, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, H302, N,N'-(1,4-phenylene)diacetamide, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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6OM6
 | | Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Hoffer, E.D, Mehrani, A, Keiler, K.C, Stagg, S.M, Dunham, C.M. | | 登録日 | 2019-04-18 | | 公開日 | 2021-02-10 | | 最終更新日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo.
Nat Commun, 12, 2021
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8PTP
 | | Structure of Rho pentamer in complex with Rof | | 分子名称: | Protein rof, Transcription termination factor Rho | | 著者 | Said, N, Hilal, T, Wahl, M.C. | | 登録日 | 2023-07-14 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation.
Nat Commun, 15, 2024
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8PTN
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8PTG
 | | Structure of the transcription termination factor Rho bound to RNA at the PBS and SBS | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Said, N, Hilal, T, Wahl, M.C. | | 登録日 | 2023-07-14 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation.
Nat Commun, 15, 2024
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8PTM
 | | Structure of the transcription termination factor Rho in complex with Rof and ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein rof, ... | | 著者 | Said, N, Hilal, T, Wahl, M.C. | | 登録日 | 2023-07-14 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation.
Nat Commun, 15, 2024
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8PTO
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5ENS
 | | Rhodamine bound structure of bacterial efflux pump. | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, RHODAMINE 6G | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENO
 | | MBX2319 bound structure of bacterial efflux pump. | | 分子名称: | 3,3-dimethyl-8-morpholin-4-yl-6-(2-phenylethylsulfanyl)-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5EN5
 | | Apo structure of bacterial efflux pump. | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENP
 | | MBX2931 bound structure of bacterial efflux pump. | | 分子名称: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENQ
 | | MBX3132 bound structure of bacterial efflux pump. | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{R})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]ethanamide | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENT
 | | Minocycline bound structure of bacterial efflux pump. | | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENR
 | | MBX3135 bound structure of bacterial efflux pump. | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{S})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]prop-2-enamide | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7UXO
 | | Structure of PDL1 in complex with FP30790, a Helicon Polypeptide | | 分子名称: | AMINO GROUP, FP30790, N,N'-(1,4-phenylene)diacetamide, ... | | 著者 | Li, K, Agarwal, S, Tokareva, O, Thomson, T, Travaline, T, Tattersfield, H, Wahl, S, Verdine, G, McGee, J. | | 登録日 | 2022-05-05 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries.
Proc.Natl.Acad.Sci.USA, 119, 2022
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