7BSJ
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![BU of 7bsj by Molmil](/molmil-images/mine/7bsj) | Crystal structure of human ME2 R484W | 分子名称: | FUMARIC ACID, MAGNESIUM ION, NAD-dependent malic enzyme, ... | 著者 | Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C. | 登録日 | 2020-03-30 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme. Iscience, 24, 2021
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7BSK
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![BU of 7bsk by Molmil](/molmil-images/mine/7bsk) | Crystal structure of human ME2 R67Q mutant | 分子名称: | NAD-dependent malic enzyme, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C. | 登録日 | 2020-03-30 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme. Iscience, 24, 2021
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7CGY
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![BU of 7cgy by Molmil](/molmil-images/mine/7cgy) | Human DMC1 Q244M mutant of the post-synaptic complexes | 分子名称: | CALCIUM ION, Meiotic recombination protein DMC1/LIM15 homolog, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Chi, H.Y, Ho, M.C, Tsai, M.D, Luo, S.C, Yeh, H.Y. | 登録日 | 2020-07-03 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C9C
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![BU of 7c9c by Molmil](/molmil-images/mine/7c9c) | Human DMC1 pre-synaptic complexes | 分子名称: | CALCIUM ION, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Meiotic recombination protein DMC1/LIM15 homolog, ... | 著者 | Luo, S.C, Yeh, H.Y, Chi, P, Ho, M.C, Tsai, M.D. | 登録日 | 2020-06-05 | 公開日 | 2020-11-25 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C99
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![BU of 7c99 by Molmil](/molmil-images/mine/7c99) | Human DMC1 post-synaptic complexes with mismatched dsDNA | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | 著者 | Luo, S.C, Yeh, H.Y, Chi, P, Ho, M.C, Tsai, M.D. | 登録日 | 2020-06-05 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C9A
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![BU of 7c9a by Molmil](/molmil-images/mine/7c9a) | Human RAD51 post-synaptic complexes mutant (V273P, D274G) | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | 著者 | Chi, H.Y, Ho, M.C, Tsai, M.D, Luo, S.C, Yeh, H.Y. | 登録日 | 2020-06-05 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C98
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![BU of 7c98 by Molmil](/molmil-images/mine/7c98) | Human DMC1 post-synaptic complexes | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | 著者 | Luo, S.C, Yeh, H.Y, Chi, P, Ho, M.C, Tsai, M.D. | 登録日 | 2020-06-05 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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5BYW
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![BU of 5byw by Molmil](/molmil-images/mine/5byw) | |
4U3A
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![BU of 4u3a by Molmil](/molmil-images/mine/4u3a) | Crystal structure of CtCel5E | 分子名称: | Endoglucanase H | 著者 | Yuan, S.F, Liang, P.H, Ho, M.C. | 登録日 | 2014-07-19 | 公開日 | 2015-01-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Biochemical Characterization and Structural Analysis of a Bifunctional Cellulase/Xylanase from Clostridium thermocellum J.Biol.Chem., 290, 2015
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4GKA
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![BU of 4gka by Molmil](/molmil-images/mine/4gka) | Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with phosphate | 分子名称: | GLYCEROL, PHOSPHATE ION, Purine nucleoside phosphorylase | 著者 | Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L. | 登録日 | 2012-08-10 | 公開日 | 2013-02-06 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol., 20, 2013
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4EAR
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![BU of 4ear by Molmil](/molmil-images/mine/4ear) | Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate | 分子名称: | 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase | 著者 | Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L. | 登録日 | 2012-03-22 | 公開日 | 2013-02-06 | 最終更新日 | 2013-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol., 20, 2013
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4ECE
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![BU of 4ece by Molmil](/molmil-images/mine/4ece) | Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine | 分子名称: | GUANINE, Purine nucleoside phosphorylase | 著者 | Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L. | 登録日 | 2012-03-26 | 公開日 | 2013-02-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol., 20, 2013
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3HIQ
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3HIV
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![BU of 3hiv by Molmil](/molmil-images/mine/3hiv) | Crystal structure of Saporin-L1 in complex with the trinucleotide inhibitor, a transition state analogue | 分子名称: | (2R,3R,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(3R,4R)-4-({[(S)-{[(2R,3R,4R,5R)-5-(2-amino-6-oxo-6,8-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl]oxy}(hydroxy)phosphoryl]oxy}methyl)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidin-3-yl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-methoxytetrahydrofuran-3-yl 3-hydroxypropyl hydrogen (S)-phosphate, Vacuolar saporin | 著者 | Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L. | 登録日 | 2009-05-20 | 公開日 | 2009-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106, 2009
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3HIT
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![BU of 3hit by Molmil](/molmil-images/mine/3hit) | Crystal structure of Saporin-L1 in complex with the dinucleotide inhibitor, a transition state analogue | 分子名称: | 5'-O-[(S)-{[(3R,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[(S)-hydroxy(3-hydroxypropoxy)phosphoryl]oxy}methyl)pyrrolidin-3-yl]oxy}(hydroxy)phosphoryl]-3'-O-[(R)-hydroxy(4-hydroxybutoxy)phosphoryl]-2'-O-methylguanosine, Vacuolar saporin | 著者 | Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L. | 登録日 | 2009-05-20 | 公開日 | 2009-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106, 2009
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3HIO
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![BU of 3hio by Molmil](/molmil-images/mine/3hio) | Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue | 分子名称: | 9,9'-{(2R,3R,3aR,5S,7aR,9R,10R,10aR,12S,23R,25aR,27R,28R,28aR,30S,32aR,35aR,37S,39aR)-9-(6-amino-9H-purin-9-yl)-34-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5,12,23,30,37-pentahydroxy-3,10,28-trimethoxy-5,12,23,30,37-pentaoxidotetracosahydro-2H,7H,25H-trifuro[3,2-f:3',2'-l:3'',2''-x]pyrrolo[3,4-r][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]undecaoxazapentaphosphacyclopentatriacontine-2,27-diyl}bis(2-amino-3,9-dihydro-6H-purin-6-one), Ricin, SULFATE ION | 著者 | Ho, M, Sturm, M.B, Goldman, J.D, Almo, S.C, Schramm, V.L. | 登録日 | 2009-05-20 | 公開日 | 2009-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106, 2009
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3HIW
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![BU of 3hiw by Molmil](/molmil-images/mine/3hiw) | Crystal structure of Saporin-L1 in complex with the cyclic tetranucleotide inhibitor, a transition state analogue | 分子名称: | 9,9'-{(2R,3R,3aR,5S,7aR,9R,10R,10aR,12S,23R,25aR,27R,28R,28aR,30S,32aR,35aR,37S,39aR)-9-(6-amino-9H-purin-9-yl)-34-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5,12,23,30,37-pentahydroxy-3,10,28-trimethoxy-5,12,23,30,37-pentaoxidotetracosahydro-2H,7H,25H-trifuro[3,2-f:3',2'-l:3'',2''-x]pyrrolo[3,4-r][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]undecaoxazapentaphosphacyclopentatriacontine-2,27-diyl}bis(2-amino-3,9-dihydro-6H-purin-6-one), Vacuolar saporin | 著者 | Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L. | 登録日 | 2009-05-20 | 公開日 | 2009-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106, 2009
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3BH2
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![BU of 3bh2 by Molmil](/molmil-images/mine/3bh2) | |
3HIS
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![BU of 3his by Molmil](/molmil-images/mine/3his) | |
3BGT
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![BU of 3bgt by Molmil](/molmil-images/mine/3bgt) | |
3BH3
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![BU of 3bh3 by Molmil](/molmil-images/mine/3bh3) | |
4G56
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![BU of 4g56 by Molmil](/molmil-images/mine/4g56) | Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis | 分子名称: | Hsl7 protein, MGC81050 protein, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Ho, M, Wilczek, C, Bonanno, J, Shechter, D, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2012-07-17 | 公開日 | 2012-10-03 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity Plos One, 8, 2013
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8IO9
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![BU of 8io9 by Molmil](/molmil-images/mine/8io9) | |
8IOA
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8IO7
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![BU of 8io7 by Molmil](/molmil-images/mine/8io7) | |