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7M7L
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BU of 7m7l by Molmil
Human DNA Pol eta with dA-ended primer and dAMPNPP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-28
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M7U
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BU of 7m7u by Molmil
Human DNA Pol eta S113A with dT-ended primer and dATP: in crystallo reaction for 480s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-28
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M8A
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BU of 7m8a by Molmil
Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 40 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-29
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
6M7P
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BU of 6m7p by Molmil
Human DNA polymerase eta extension complex with cdA at the -2 position
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*CP*(02I)P*CP*AP*CP*AP*CP*T)-3'), ...
著者Gregory, M.T, Yang, W.
登録日2018-08-20
公開日2018-09-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4DL7
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BU of 4dl7 by Molmil
Human DNA polymerase eta fails to extend primer 2 nucleotide after cisplatin crosslink (Pt-GG4).
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*TP*AP*CP*TP*CP*GP*GP*TP*CP*AP*CP*T)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
4DL2
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BU of 4dl2 by Molmil
Human DNA polymerase eta inserting dCMPNPP opposite CG template (GG0a)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
3MR5
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Human DNA polymerase eta - DNA ternary complex with a CPD 1bp upstream of the active site (TT3)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*CP*GP*TP*CP*AP*TP*AP*A)-3'), DNA (5'-D(*TP*AP*AP*CP*(TTD)P*AP*TP*GP*AP*CP*GP*A)-3'), ...
著者Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W.
登録日2010-04-28
公開日2010-06-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
3MR2
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Human DNA polymerase eta in complex with normal DNA and incoming nucleotide (Nrm)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*T*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W.
登録日2010-04-28
公開日2010-06-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
3MR6
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Human DNA polymerase eta - DNA ternary complex with a CPD 2bp upstream of the active site (TT4)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*C*AP*TP*CP*AP*(TTD)P*AP*CP*GP*AP*GP*C)-3'), DNA (5'-D(*TP*CP*TP*CP*GP*TP*AP*AP*T)-3'), ...
著者Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W.
登録日2010-04-28
公開日2010-06-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
3MR3
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BU of 3mr3 by Molmil
Human DNA polymerase eta - DNA ternary complex with the 3'T of a CPD in the active site (TT1)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*(TTD)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W.
登録日2010-04-28
公開日2010-06-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
4DL3
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BU of 4dl3 by Molmil
Human DNA polymerase eta inserting dCMPNPP opposite GG template (GG0b).
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*C)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
4DL6
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BU of 4dl6 by Molmil
Human DNA polymerase eta extending primer immediately after cisplatin crosslink (Pt-GG3).
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Cisplatin, DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*CP*C)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
4DL5
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BU of 4dl5 by Molmil
Human DNA polymerase eta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2).
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Cisplatin, DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hanaoka, F, Hua, Y, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
4DL4
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BU of 4dl4 by Molmil
Human DNA polymerase eta inserting dCMPNPP opposite the 3'G of cisplatin crosslinked Gs (Pt-GG1).
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Cisplatin, DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y.-J, Hanaoka, F, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
6M7V
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BU of 6m7v by Molmil
Human DNA polymerase eta extension complex with cdA at the -1 position
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(P*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(P*GP*TP*GP*TP*GP*AP*GP*T)-3'), ...
著者Weng, P, Gao, Y, Yang, W.
登録日2018-08-21
公開日2018-09-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.062 Å)
主引用文献Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7O
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BU of 6m7o by Molmil
Human DNA polymerase eta ternary complex with Mn2+ and dTMPNPP oppositing cdA
分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*TP*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(P*AP*GP*TP*GP*TP*GP*AP*G*(1FZ))-3'), ...
著者Weng, P, Gao, Y, Yang, W.
登録日2018-08-20
公開日2018-09-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7T
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BU of 6m7t by Molmil
Human DNA polymerase eta in a non-productive ternary complex with Ca2+ and dTTP oppositing cdA
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ...
著者Weng, P, Gao, Y, Yang, W.
登録日2018-08-21
公開日2018-09-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7U
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BU of 6m7u by Molmil
Human DNA polymerase eta in a non-productive ternary complex with Mg2+ and dTMPNPP oppositing cdA
分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, CHLORIDE ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ...
著者Weng, P, Gao, Y, Yang, W.
登録日2018-08-21
公開日2018-09-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4J9R
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BU of 4j9r by Molmil
Human DNA polymerase eta-DNA translocated binary complex with TG mispair
分子名称: DNA (5'-D(*T*AP*CP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*CP*AP*TP*G)-3'), DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J9S
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BU of 4j9s by Molmil
Human DNA polymerase eta-DNA translocated binary complex: with TA base pair
分子名称: DNA (5'-D(*T*AP*TP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*AP*TP*A)-3'), DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J9K
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BU of 4j9k by Molmil
Human DNA polymerase eta-DNA ternary complex: misincorporation G opposite T after a T at the primer 3' end (TA/G)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA, DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J9P
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BU of 4j9p by Molmil
Human DNA polymerase eta-DNA postinsertion binary complex with TA base pair
分子名称: DNA (5'-D(*C*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*TP*A)-3'), DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J9L
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BU of 4j9l by Molmil
Human DNA polymerase eta-DNA ternary complex: misincorporation G opposite T after a C at the primer 3' end (CA/G)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA, DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J9N
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BU of 4j9n by Molmil
Human DNA polymerase eta-DNA ternary complex: misincorporation G opposite T after a G at the primer 3' end (GA/G)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA, DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.956 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J9M
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BU of 4j9m by Molmil
Human DNA polymerase eta-DNA ternary complex: misincorporation G opposite T after an A at the primer 3' end (AA/G)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA, DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013

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