3A50
 
 | | Structure of cytochrome P450 Vdh mutant (Vdh-K1) obtained by directed evolution with bound vitamin D3 | | 分子名称: | (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL, ACETATE ION, CALCIUM ION, ... | | 著者 | Yasutake, Y, Fujii, Y, Cheon, W.K, Arisawa, A, Tamura, T. | | 登録日 | 2009-07-24 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural evidence for enhancement of sequential vitamin D3 hydroxylation activities by directed evolution of cytochrome P450 vitamin D3 hydroxylase
J.Biol.Chem., 285, 2010
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3A4G
 | | Structure of cytochrome P450 vdh from Pseudonocardia autotrophica (trigonal crystal form) | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, PROTOPORPHYRIN IX CONTAINING FE, Vitamin D hydroxylase | | 著者 | Yasutake, Y, Fujii, Y, Cheon, W.K, Arisawa, A, Tamura, T. | | 登録日 | 2009-07-07 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural evidence for enhancement of sequential vitamin D3 hydroxylation activities by directed evolution of cytochrome P450 vitamin D3 hydroxylase
J.Biol.Chem., 285, 2010
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1WKR
 | | Crystal structure of aspartic proteinase from Irpex lacteus | | 分子名称: | Polyporopepsin, SULFATE ION, pepstatin | | 著者 | Fujimoto, Z, Fujii, Y, Kaneko, S, Kobayashi, H, Mizuno, H. | | 登録日 | 2004-06-02 | | 公開日 | 2004-09-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystal Structure of Aspartic Proteinase from Irpex lacteus in Complex with Inhibitor Pepstatin
J.Mol.Biol., 341, 2004
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1MPG
 | | 3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI | | 分子名称: | 3-METHYLADENINE DNA GLYCOSYLASE II, GLYCEROL | | 著者 | Labahn, J, Schaerer, O.D, Long, A, Ezaz-Nikpay, K, Verdine, G.L, Ellenberger, T.E. | | 登録日 | 1997-10-28 | | 公開日 | 1998-01-28 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for the excision repair of alkylation-damaged DNA.
Cell(Cambridge,Mass.), 86, 1996
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1PD2
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5XCR
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5XCX
 | | Crystal structure of TS2/16 Fv-clasp fragment | | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Arimori, T, Takagi, J. | | 登録日 | 2017-03-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability
Structure, 25, 2017
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5XG5
 | | Crystal structure of Mitsuba-1 with bound NAcGal | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, MITSUBA-1 | | 著者 | Terada, D, Voet, A.R.D, Kamata, K, Zhang, K.Y.J, Tame, J.R.H. | | 登録日 | 2017-04-12 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Computational design of a symmetrical beta-trefoil lectin with cancer cell binding activity.
Sci Rep, 7, 2017
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5XCS
 | | Crystal structure of 12CA5 Fv-clasp fragment with its antigen peptide | | 分子名称: | HA peptide, SULFATE ION, VH-SARAH(Y35C) chimera, ... | | 著者 | Arimori, T, Takagi, J. | | 登録日 | 2017-03-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability
Structure, 25, 2017
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6LF1
 | | SeviL, a GM1b/asialo-GM1 binding lectin | | 分子名称: | CHLORIDE ION, SeviL | | 著者 | Kamata, K, Ozeki, Y, Park, S.-Y, Tame, J.R.H. | | 登録日 | 2019-11-28 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The structure of SeviL, a GM1b/asialo-GM1 binding R-type lectin from the mussel Mytilisepta virgata.
Sci Rep, 10, 2020
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6LF2
 | | SeviL bound to asialo-GM1 saccharide | | 分子名称: | SeviL, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Kamata, K, Ozeki, Y, Park, S.-Y, Tame, J.R.H. | | 登録日 | 2019-11-28 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The structure of SeviL, a GM1b/asialo-GM1 binding R-type lectin from the mussel Mytilisepta virgata.
Sci Rep, 10, 2020
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8IFJ
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5XCQ
 | | Crystal structure of P20.1 Fv-clasp fragment with its antigen peptide | | 分子名称: | C8 peptide, SULFATE ION, VH-SARAH(Y35C)chimera, ... | | 著者 | Arimori, T, Takagi, J. | | 登録日 | 2017-03-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.313 Å) | | 主引用文献 | Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability
Structure, 25, 2017
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5XCU
 | | Crystal structure of 12CA5 Fv-clasp fragment with its antigen peptide | | 分子名称: | HA peptide, SULFATE ION, VH(S112C)-SARAH chimera,VH(S112C)-SARAH chimera, ... | | 著者 | Arimori, T, Takagi, J. | | 登録日 | 2017-03-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.454 Å) | | 主引用文献 | Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability
Structure, 25, 2017
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5XCV
 | | Crystal structure of NZ-1 Fv-clasp fragment with its antigen peptide | | 分子名称: | CALCIUM ION, PA14 peptide, VH(S112C)-SARAH chimera,VH(S112C)-SARAH chimera, ... | | 著者 | Arimori, T, Takagi, J. | | 登録日 | 2017-03-23 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.143 Å) | | 主引用文献 | Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability
Structure, 25, 2017
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5XCT
 | | Crystal structure of P20.1 Fv-clasp fragment with its antigen peptide | | 分子名称: | C8 peptide, CHLORIDE ION, VH(S112C)-SARAH chimera, ... | | 著者 | Arimori, T, Takagi, J. | | 登録日 | 2017-03-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability
Structure, 25, 2017
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6ACR
 | | Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638 | | 分子名称: | Activin receptor type-1, N-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine, SULFATE ION | | 著者 | Sakai, N, Mishima-Tsumagari, C, Matsumoto, T, Shirouzu, M. | | 登録日 | 2018-07-27 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Chem. Pharm. Bull., 67, 2019
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6K4H
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6JUX
 | | Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-71807 | | 分子名称: | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine, Activin receptor type-1, SULFATE ION | | 著者 | Sakai, N, Mishima-Tsumagari, C, Matsumoto, T, Shirouzu, M. | | 登録日 | 2019-04-15 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.
Acs Omega, 5, 2020
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6K4G
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7ED6
 | | Crystal structure of Thermus thermophilus FakA ATP-binding domain | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Probable kinase | | 著者 | Nakatani, M, Nakahara, S, Fukui, K, Murakawa, T, Masui, R. | | 登録日 | 2021-03-15 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-01-11 | | 実験手法 | X-RAY DIFFRACTION (1.92850327 Å) | | 主引用文献 | Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8.
J.Struct.Biol., 214, 2022
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7ED9
 | | Crystal structure of selenomethionine-labeled Thermus thermophilus FakA ATP-binding domain | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Probable kinase | | 著者 | Nakatani, M, Nakahara, S, Fukui, K, Murakawa, T, Masui, R. | | 登録日 | 2021-03-15 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.01764154 Å) | | 主引用文献 | Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8.
J.Struct.Biol., 214, 2022
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7EM6
 | | Crystal structure of the PI5P4Kbeta N203D-ITP complex | | 分子名称: | INOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Senda, M, Senda, T. | | 登録日 | 2021-04-13 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity.
Structure, 30, 2022
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7EM7
 | | Crystal structure of the PI5P4Kbeta N203D-XTP complex | | 分子名称: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Senda, M, Senda, T. | | 登録日 | 2021-04-13 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity.
Structure, 30, 2022
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7EM5
 | | Crystal structure of the PI5P4Kbeta F205L-XTP complex | | 分子名称: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Senda, M, Senda, T. | | 登録日 | 2021-04-13 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity.
Structure, 30, 2022
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