7EM5

Crystal structure of the PI5P4Kbeta F205L-XTP complex

Summary for 7EM5

• Entry DOI: 10.2210/pdb7em5/pdb
• Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (4 entities in total)
• Functional Keywords: lipid kinase, phosphoinositide signaling, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 91202.31

Authors

Senda, M.,Senda, T. (deposition date: 2021-04-13, release date: 2022-03-30, Last modification date: 2023-11-29)

• Primary citation: Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T.; The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity.; Structure, 30:886-899.e4, 2022; PubMed: 35504278; DOI: 10.1016/j.str.2022.04.004

Experimental method

X-RAY DIFFRACTION (2.8 Å)