6K4G

Crystal structure of the PI5P4Kbeta-GMPPNP complex

Summary for 6K4G

Entry DOI	10.2210/pdb6k4g/pdb
Descriptor	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER (3 entities in total)
Functional Keywords	lipid kinase, phosphoinositide signaling, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	91424.39
Authors	Takeuchi, K.,Senda, M.,Senda, T. (deposition date: 2019-05-23, release date: 2020-05-27, Last modification date: 2023-11-22)
Primary citation	Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T. The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 2022 Cited by PubMed: 35504278 DOI: 10.1016/j.str.2022.04.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation