6JUX

Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-71807

Summary for 6JUX

Entry DOI	10.2210/pdb6jux/pdb
Descriptor	Activin receptor type-1, 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34931.99
Authors	Sakai, N.,Mishima-Tsumagari, C.,Matsumoto, T.,Shirouzu, M. (deposition date: 2019-04-15, release date: 2020-04-15, Last modification date: 2023-11-22)
Primary citation	Sato, T.,Sekimata, K.,Sakai, N.,Watanabe, H.,Mishima-Tsumagari, C.,Taguri, T.,Matsumoto, T.,Fujii, Y.,Handa, N.,Tanaka, A.,Shirouzu, M.,Yokoyama, S.,Hashizume, Y.,Miyazono, K.,Koyama, H.,Honma, T. Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches. Acs Omega, 5:11411-11423, 2020 Cited by PubMed: 32478230 DOI: 10.1021/acsomega.9b04245 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation