6JUX
Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-71807
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Activin receptor type-1 | polymer | 299 | 34313.4 | 1 | UniProt (Q04771) Pfam (PF00069) In PDB | Homo sapiens (Human) | |
| 2 | A | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | non-polymer | 426.5 | 1 | Chemie (C9U) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| His 206 | Arg 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34313.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 618.6 | |
| All* | Total formula weight | 34932.0 |
