6ACR

Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638

Summary for 6ACR

• Entry DOI: 10.2210/pdb6acr/pdb
• Descriptor: Activin receptor type-1, N-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, kinase, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 70328.37

Authors

Sakai, N.,Mishima-Tsumagari, C.,Matsumoto, T.,Shirouzu, M. (deposition date: 2018-07-27, release date: 2019-03-20, Last modification date: 2023-11-22)

• Primary citation: Sekimata, K.,Sato, T.,Sakai, N.,Watanabe, H.,Mishima-Tsumagari, C.,Taguri, T.,Matsumoto, T.,Fujii, Y.,Handa, N.,Honma, T.,Tanaka, A.,Shirouzu, M.,Yokoyama, S.,Miyazono, K.,Hashizume, Y.,Koyama, H.; Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).; Chem. Pharm. Bull., 67:224-235, 2019; PubMed: 30828000; DOI: 10.1248/cpb.c18-00598

Experimental method

X-RAY DIFFRACTION (2.01 Å)