6ACR
Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Activin receptor type-1 | polymer | 301 | 34531.6 | 2 | UniProt (Q04771) Pfam (PF07714) In PDB | Homo sapiens (Human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
| 2 | A, B | N-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | non-polymer | 344.4 | 2 | Chemie (9TO) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| His 206 | Arg 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69063.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1265.1 | |
| All* | Total formula weight | 70328.4 |
