Search by PDB author

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10r
分子名称:	CARBONATE ION, GLYCEROL, N-{(1R)-2-(hydroxyamino)-1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-2-oxoethyl}-2,2-dimethylpropanamide, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-21
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

3KQM

Crystal Structure of hPNMT in Complex AdoHcy and 4-Bromo-1H-imidazole
分子名称:	4-bromo-1H-imidazole, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KPY

Crystal Structure of hPNMT in Complex AdoHcy and 6-Chlorooxindole
分子名称:	6-chloro-1,3-dihydro-2H-indol-2-one, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQV

Crystal Structure of hPNMT in Complex AdoHcy and Formanilide
分子名称:	FORMANILIDE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KR2

Crystal Structure of hPNMT in Complex AdoHcy and 5-fluoro-1H-benzo[d]imidazol-2-amine
分子名称:	6-fluoro-1H-benzimidazol-2-amine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KPW

Crystal Structure of hPNMT in Complex AdoHcy and 1-Aminoisoquinoline
分子名称:	ISOQUINOLIN-1-AMINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQP

Crystal Structure of hPNMT in Complex AdoHcy and 6-Aminoquinoline
分子名称:	Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, quinolin-6-amine
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQT

Crystal Structure of hPNMT in Complex AdoHcy and 2-Amino-1-methylbenzimidazole
分子名称:	1-methyl-1H-benzimidazol-2-amine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.399 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KPU

Crystal Structure of hPNMT in Complex AdoHcy and 4-quinolinol
分子名称:	Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, quinolin-4-ol
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KR0

Crystal Structure of hPNMT in Complex AdoHcy and 2-amino-1H-benzo[d]imidazol-6-ol
分子名称:	2-AMINO-5-HYDROXY-BENZIMIDAZOLE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQS

Crystal Structure of hPNMT in Complex AdoHcy and 2-Aminobenzimidazole
分子名称:	1H-benzimidazol-2-amine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.005 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KPJ

Crystal Structure of hPNMT in Complex AdoHcy and Bound Phosphate
分子名称:	PHOSPHATE ION, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-16
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQW

Crystal Structure of hPNMT in Complex AdoHcy and 5-Chlorobenzimidazole
分子名称:	5-chloro-1H-benzimidazole, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.486 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KPV

Crystal Structure of hPNMT in Complex AdoHcy and Adenine
分子名称:	ADENINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQQ

Crystal Structure of hPNMT in Complex AdoHcy and 2-Hydroxynicotinic acid
分子名称:	2-oxo-1,2-dihydropyridine-3-carboxylic acid, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQY

Crystal Structure of hPNMT in Complex AdoHcy and 2-amino-1H-benzo[d]imidazol-7-ol
分子名称:	2-amino-1H-benzimidazol-7-ol, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KQO

Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine
分子名称:	6-chloro-9H-purine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

3KR1

Crystal Structure of hPNMT in Complex AdoHcy and 5-chloro-1H-benzo[d]imidazol-2-amine
分子名称:	6-chloro-1H-benzimidazol-2-amine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-11-17
公開日	2010-09-29
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010

4R5X

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
分子名称:	3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者	Drinkwater, N, Mcgowan, S.
登録日	2014-08-22
公開日	2014-10-29
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R76

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
分子名称:	3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, M17 family aminopeptidase, ...
著者	Drinkwater, N, Mcgowan, S.
登録日	2014-08-27
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R5T

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, Mcgowan, S.
登録日	2014-08-22
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R6T

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
分子名称:	CARBONATE ION, DIMETHYL SULFOXIDE, M17 leucyl aminopeptidase, ...
著者	Drinkwater, N, Mcgowan, S.
登録日	2014-08-26
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

2ONZ

Structure of K57A hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy
分子名称:	N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2007-01-25
公開日	2007-10-09
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007

2OPB

Structure of K57A hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoHcy
分子名称:	(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, PHOSPHATE ION, Phenylethanolamine N-methyltransferase, ...
著者	Drinkwater, N, Martin, J.L.
登録日	2007-01-28
公開日	2007-10-09
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase. J.Med.Chem., 50, 2007

2ONY

Structure of hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy
分子名称:	N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, PHOSPHATE ION, Phenylethanolamine N-methyltransferase, ...
著者	Drinkwater, N, Martin, J.L.
登録日	2007-01-24
公開日	2007-10-09
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007

<123 4 5 >

全ヒット件数:	111
表示件数:	25
表示順	関連性が高い順