2OPB
Structure of K57A hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoHcy
Summary for 2OPB
Entry DOI | 10.2210/pdb2opb/pdb |
Related | 1HNN 2G8N |
Descriptor | Phenylethanolamine N-methyltransferase, (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total) |
Functional Keywords | methyltransferase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65100.40 |
Authors | Drinkwater, N.,Martin, J.L. (deposition date: 2007-01-28, release date: 2007-10-09, Last modification date: 2023-08-30) |
Primary citation | Gee, C.L.,Drinkwater, N.,Tyndall, J.D.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase. J.Med.Chem., 50:4845-4853, 2007 Cited by PubMed: 17845018DOI: 10.1021/jm0703385 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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