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2ONZ

Structure of K57A hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy

Summary for 2ONZ
Entry DOI10.2210/pdb2onz/pdb
Related1HNN 2G8N 2ONY
DescriptorPhenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, ... (4 entities in total)
Functional Keywordsmethyltransferase, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight64990.17
Authors
Drinkwater, N.,Martin, J.L. (deposition date: 2007-01-25, release date: 2007-10-09, Last modification date: 2023-10-25)
Primary citationGee, C.L.,Drinkwater, N.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L.
Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
J.Med.Chem., 50:4845-4853, 2007
Cited by
PubMed: 17845018
DOI: 10.1021/jm0703385
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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