6YUF
| Cohesin complex with loader gripping DNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit rad21, ... | 著者 | Higashi, T.L, Eickhoff, P, Sousa, J.S, Costa, A, Uhlmann, F. | 登録日 | 2020-04-27 | 公開日 | 2020-08-19 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | A Structure-Based Mechanism for DNA Entry into the Cohesin Ring. Mol.Cell, 79, 2020
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7P30
| 3.0 A resolution structure of a DNA-loaded MCM double hexamer | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (53-MER), ... | 著者 | Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. | 登録日 | 2021-07-06 | 公開日 | 2022-02-02 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
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7P5Z
| Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 7, ... | 著者 | Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. | 登録日 | 2021-07-15 | 公開日 | 2022-02-02 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
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8QYI
| OleP in complex with lithocholic acid in high salt crystallization conditions | 分子名称: | (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, Cytochrome P-450, FORMIC ACID, ... | 著者 | Fata, F, Costanzo, A, Freda, I, Gugole, E, Bulfaro, G, Barbizzi, L, Di Renzo, M, Savino, C, Vallone, B, Montemiglio, L.C. | 登録日 | 2023-10-26 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | OleP in complex with lithocolic acid in high salt crystallization conditions To Be Published
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8QRD
| OleP in complex with testosterone in high salt crystallization conditions | 分子名称: | Cytochrome P-450, FORMIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Fata, F, Costanzo, A, Freda, I, Gugole, E, Bulfaro, G, Barbizzi, L, Di Renzo, M, Savino, C, Vallone, B, Montemiglio, L.C. | 登録日 | 2023-10-06 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | OleP in complex with testosterone in high salt crystallization conditions To Be Published
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8B29
| Human carbonic anhydrase II containing 6-fluorotryptophanes. | 分子名称: | Carbonic anhydrase 2, ZINC ION | 著者 | Pham, L.B.T, Costantino, A, Barbieri, L, Calderone, V, Luchinat, E, Banci, L. | 登録日 | 2022-09-13 | 公開日 | 2023-01-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Direct Expression of Fluorinated Proteins in Human Cells for 19 F In-Cell NMR Spectroscopy. J.Am.Chem.Soc., 145, 2023
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4NW6
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4NW5
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6ZHY
| Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic patch: hexasome class. | 分子名称: | Chromodomain-helicase-DNA-binding protein 1-like, DNA (110-MER) Widom 601 sequence, Histone H2A type 1, ... | 著者 | Bacic, L, Gaullier, G, Deindl, S. | 登録日 | 2020-06-24 | 公開日 | 2020-12-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. Cell Rep, 33, 2020
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4U7D
| Structure of human RECQ-like helicase in complex with an oligonucleotide | 分子名称: | ATP-dependent DNA helicase Q1, DNA oligonucleotide, ZINC ION | 著者 | Pike, A.C.W, Zhang, Y, Schnecke, C, Cooper, C.D.O, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O, Structural Genomics Consortium (SGC) | 登録日 | 2014-07-30 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures. Proc.Natl.Acad.Sci.USA, 112, 2015
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5HOG
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8P5E
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8P62
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8P63
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3UL6
| Saccharum officinarum canecystatin-1 in space group P6422 | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Canecystatin-1 | 著者 | Valadares, N.F, Pereira, H.M, Oliveira-Silva, R, Garratt, R.C. | 登録日 | 2011-11-10 | 公開日 | 2012-12-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | X-ray crystallography and NMR studies of domain-swapped canecystatin-1. Febs J., 280, 2013
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3UL5
| Saccharum officinarum canecystatin-1 in space group C2221 | 分子名称: | Canecystatin-1, GLYCEROL, SODIUM ION | 著者 | Valadares, N.F, Pereira, H.M, Oliveira-Silva, R, Garratt, R.C. | 登録日 | 2011-11-10 | 公開日 | 2012-11-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | X-ray crystallography and NMR studies of domain-swapped canecystatin-1. Febs J., 280, 2013
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5T3A
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5LLJ
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6YUW
| STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 454 | 分子名称: | 1-(cyclopropylmethyl)-2,5-dimethyl-pyrrole-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Ruza, R.R, Hillier, J, Jones, E.Y. | 登録日 | 2020-04-27 | 公開日 | 2020-05-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63, 2020
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6YV2
| STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLIDINE-3-CARBOXYLIC ACID FRAGMENT 598 | 分子名称: | (3~{R})-1-phenylpyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ruza, R.R, Hillier, J, Jones, E.Y. | 登録日 | 2020-04-27 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63, 2020
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6YXI
| Structure of Notum in complex with a 1-(3-Chlorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid inhibitor | 分子名称: | 1,2-ETHANEDIOL, 1-(3-chlorophenyl)-2,5-dimethyl-pyrrole-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Vecchia, L, Jones, E.Y, Ruza, R.R, Hillier, J, Zhao, Y. | 登録日 | 2020-05-01 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63, 2020
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6YV4
| STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 686 | 分子名称: | 1,2-ETHANEDIOL, 1-cyclopropyl-2,5-dimethyl-pyrrole-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hillier, J, Ruza, R.R, Jones, E.Y. | 登録日 | 2020-04-27 | 公開日 | 2020-05-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63, 2020
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6YV0
| STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLIDINE-3-CARBOXYLIC ACID FRAGMENT 587 | 分子名称: | (3~{R})-1-(2-chlorophenyl)pyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ruza, R.R, Hillier, J, Jones, E.Y. | 登録日 | 2020-04-27 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63, 2020
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6YUY
| STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 471 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methyl-5-(trifluoromethyl)-1~{H}-pyrrole-3-carboxylic acid, DIMETHYL SULFOXIDE, ... | 著者 | Hillier, J, Ruza, R.R, Jones, E.Y. | 登録日 | 2020-04-27 | 公開日 | 2020-05-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63, 2020
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6YSK
| 1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of Notum | 分子名称: | (3~{S})-1-[4-chloranyl-3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | 登録日 | 2020-04-22 | 公開日 | 2020-09-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63, 2020
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