6YUY

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 471

Summary for 6YUY

Entry DOI	10.2210/pdb6yuy/pdb
Descriptor	Palmitoleoyl-protein carboxylesterase NOTUM, SULFATE ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	wnt, wnt signalling, frizzled, fzd, fragment screen, notum, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	45596.62
Authors	Hillier, J.,Ruza, R.R.,Jones, E.Y. (deposition date: 2020-04-27, release date: 2020-05-06, Last modification date: 2024-01-24)
Primary citation	Mahy, W.,Patel, M.,Steadman, D.,Woodward, H.L.,Atkinson, B.N.,Svensson, F.,Willis, N.J.,Flint, A.,Papatheodorou, D.,Zhao, Y.,Vecchia, L.,Ruza, R.R.,Hillier, J.,Frew, S.,Monaghan, A.,Costa, A.,Bictash, M.,Walter, M.W.,Jones, E.Y.,Fish, P.V. Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem., 63:9464-9483, 2020 Cited by PubMed: 32787107 DOI: 10.1021/acs.jmedchem.0c00660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation